Abstract

This project will test whether genistein?s antiproliferative effects occur through inhibition of abnormal phosphorylation of S-phase centromere proteins and nuclear mitotic apparatus protein NuMA or through reductions in free radical damage to mitochondria.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES010535-03
Application #
6575701
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$65,390
Indirect Cost

  Institution

Name
University of Missouri-Columbia
Department
Type
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211

  Publications

Lei, Wei; Browning Jr, Jimmy D; Eichen, Peggy A et al. (2015) Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by the toll-like receptor-4 signaling pathway. J Ethnopharmacol 172:247-53
Slusarz, Anna; Jackson, Glenn A; Day, J Kevin et al. (2012) Aggressive prostate cancer is prevented in ER?KO mice and stimulated in ER?KO TRAMP mice. Endocrinology 153:4160-70
Brown, Marybeth; Ning, Jie; Ferreira, J Andries et al. (2009) Estrogen receptor-alpha and -beta and aromatase knockout effects on lower limb muscle mass and contractile function in female mice. Am J Physiol Endocrinol Metab 296:E854-61
Richter, Catherine A; Taylor, Julia A; Ruhlen, Rachel L et al. (2007) Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells. Environ Health Perspect 115:902-8
Zhou, Wei; Lo, Shih-Ching; Liu, Jing-Hua et al. (2007) ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol Cell Endocrinol 278:52-62
Curran, Edward M; Tassell, Audrey Hart-Van; Judy, Barbara M et al. (2007) Estrogen increases menopausal host susceptibility to experimental ascending urinary-tract infection. J Infect Dis 195:680-3
Wang, Qun; Tompkins, Kenneth D; Simonyi, Agnes et al. (2006) Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res 1090:182-9
Zhou, Wei; Liu, Zhilin; Wu, Jianbo et al. (2006) Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta. J Clin Endocrinol Metab 91:569-79
Zhu, Donghui; Tan, Kevin S; Zhang, Xiaolin et al. (2005) Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes. J Cell Sci 118:3695-703
Ansell, P J; Lo, S-C; Newton, L G et al. (2005) Repression of cancer protective genes by 17beta-estradiol: ligand-dependent interaction between human Nrf2 and estrogen receptor alpha. Mol Cell Endocrinol 243:27-34

Showing the most recent 10 out of 34 publications