Abstract

The objectives of the Image Analysis Core are (1) to collect and analyze the information obtained from analysis of mutant mice. This will include (a) 3-D laser surface scans performed on mutant mice for subtle craniofacial and limb abnormalities, (b) digital image analysis of skeletal preparations for patterning and proliferation defects of bony and cartilaginous elements, and 8 x-rays studies at various time points to evaluate growth of skeletal elements and bone density. (2) To interact with project 2 to correlate quantitative measures of anthropometry in humans with cleidocranial dysplasia and normal controls with murine measures. The Core will systematically perform imaging studies on mice to better delineate their phenotype. The 3D laser surface methodology will be applied to the study of the phenotype of mice with craniofacial abnormalities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES011253-02
Application #
6649963
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2002-08-16
Project End
2003-05-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Chen, Shan; Grover, Monica; Sibai, Tarek et al. (2015) Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeleton. Mol Genet Metab 115:53-60
Chen, Shan; Lee, Brendan H; Bae, Yangjin (2014) Notch signaling in skeletal stem cells. Calcif Tissue Int 94:68-77
Sule, G; Campeau, P M; Zhang, V W et al. (2013) Next-generation sequencing for disorders of low and high bone mineral density. Osteoporos Int 24:2253-9
Ruan, Merry Z C; Dawson, Brian; Jiang, Ming-Ming et al. (2013) Quantitative imaging of murine osteoarthritic cartilage by phase-contrast micro-computed tomography. Arthritis Rheum 65:388-96
Choudhry, Kiran S; Grover, Monica; Tran, Alyssa A et al. (2012) Decreased bone mineralization in children with Noonan syndrome: another consequence of dysregulated RAS MAPKinase pathway? Mol Genet Metab 106:237-40
Campeau, Philippe M; Lu, James T; Dawson, Brian C et al. (2012) The KAT6B-related disorders genitopatellar syndrome and Ohdo/SBBYS syndrome have distinct clinical features reflecting distinct molecular mechanisms. Hum Mutat 33:1520-5
Li, Feifei; Lu, Yaojuan; Ding, Ming et al. (2011) Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer. J Bone Miner Res 26:2899-910
Keller, Bettina; Yang, Tao; Chen, Yuqing et al. (2011) Interaction of TGF? and BMP signaling pathways during chondrogenesis. PLoS One 6:e16421
Zheng, Lihua; Michelson, Yehudit; Freger, Vita et al. (2011) Drosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS One 6:e22956
Engin, Feyza; Lee, Brendan (2010) NOTCHing the bone: insights into multi-functionality. Bone 46:274-80

Showing the most recent 10 out of 35 publications