Abstract

The core will provide uniform, careful oversight of the animals, their diets and all the procedures for handling them and their tissues. It will provide and keep current the central repository of data related to the animals. It will provide the primary data on body weight, feed intake (where measured), development of palpable tumors, gross findings at necropsy on all animals in all projects and the histopathologic and immunohistochemical findings on the rats. Dr. Rogers will work with Dr. Cardiff to reconcile histopathologic results in the mice and rats. The core will provide uniform tissue samples and fractions to investigators for their biochemical and molecular studies. These functions will assure comparability of the animal tissues used in the three component projects and permit direct comparisons of the results of a wide variety of studies on the same tissues. These procedures promote efficient use of tissues and animals, reducing overall numbers of animals needed. Drs. Sonenshein, Sherr, and Rogers have worked closely over the past four years in a similarly-designed program and found it to be highly productive and efficient.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES011624-02
Application #
6658407
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
2002-09-09
Project End
2003-07-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Smith, Brenden W; Stanford, Elizabeth A; Sherr, David H et al. (2016) Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells Int 2016:2574152
Das, Sonia G; Romagnoli, Mathilde; Mineva, Nora D et al. (2016) miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Breast Cancer Res 18:40
Stanford, Elizabeth A; Wang, Zhongyan; Novikov, Olga et al. (2016) The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol 14:20
Romagnoli, Mathilde; Mineva, Nora D; Polmear, Michael et al. (2014) ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO Mol Med 6:278-94
Sherr, David H; Monti, Stefano (2013) The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Semin Immunopathol 35:705-16
Mineva, Nora D; Paulson, K Eric; Naber, Stephen P et al. (2013) Epigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cells. PLoS One 8:e73464
Sato, Seiichi; Zhao, Yingshe; Imai, Misa et al. (2013) Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. PLoS One 8:e77288
Smith, Brenden W; Rozelle, Sarah S; Leung, Amy et al. (2013) The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood 122:376-85
Quintana, Francisco J; Sherr, David H (2013) Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev 65:1148-61
Iskratsch, Thomas; Reijntjes, Susan; Dwyer, Joseph et al. (2013) Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci 70:893-908

Showing the most recent 10 out of 66 publications