Abstract

This Program Project will generate a very large amount of data coming from a variety of sources. It will be essential to the success of the project that these data be handled in a consistent manner and analyzed using appropriate statistical methods. The Biostatistics and Data Management Core (BDC) will fill this role, providing comprehensive data-related support to all three research projects. The types of support that will be provided by the BDC will include: designing forms and questionnaires for new data collection;processing incoming data generated by the other two Cores;data checking, including checks for logical inconsistencies and potential outliers;creating databases that combine phenotypic, genetic and exposure data;assisting in the development of hypotheses;analyzing data, including testing and estimating air pollution and genetic effects;preparing manuscripts for publication; maintaining a central computing resource that may be accessed by all investigators for file sharing and running software programs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES011627-08
Application #
7846208
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
8
Fiscal Year
2009
Total Cost
$559,253
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Weaver, Garrett M; Gauderman, W James (2018) Traffic-Related Pollutants: Exposure and Health Effects Among Hispanic Children. Am J Epidemiol 187:45-52
Zhou, Hui; Li, Xia Iona; Kim, Jeong Hee et al. (2018) Effect of inhaled allergens and air pollutants on childhood rhinitis development. Ann Allergy Asthma Immunol 120:212-214
Urman, Robert; Eckel, Sandrah; Deng, Huiyu et al. (2018) RISK EFFECTS OF NEAR-ROADWAY POLLUTANTS AND ASTHMA STATUS ON BRONCHITIC SYMPTOMS IN CHILDREN. Environ Epidemiol 2:
Kothari, Parul H; Qiu, Weiliang; Croteau-Chonka, Damien C et al. (2018) Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus. J Allergy Clin Immunol 141:2282-2286.e6
Kerin, Tara; Volk, Heather; Li, Weiyan et al. (2018) Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder. J Autism Dev Disord 48:137-150
Zhang, Yue; Salam, Muhammad T; Berhane, Kiros et al. (2017) Genetic and epigenetic susceptibility of airway inflammation to PM2.5 in school children: new insights from quantile regression. Environ Health 16:88
Chen, Zhanghua; Salam, Muhammad T; Alderete, Tanya L et al. (2017) Effects of Childhood Asthma on the Development of Obesity among School-aged Children. Am J Respir Crit Care Med 195:1181-1188
McConnell, Rob; Barrington-Trimis, Jessica L; Wang, Kejia et al. (2017) Electronic Cigarette Use and Respiratory Symptoms in Adolescents. Am J Respir Crit Care Med 195:1043-1049
Zhang, Yue; Berhane, Kiros (2016) Dynamic Latent Trait Models with Mixed Hidden Markov Structure for Mixed Longitudinal Outcomes. J Appl Stat 43:704-720
Breton, Carrie V; Yao, Jin; Millstein, Josh et al. (2016) Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study. Environ Health Perspect 124:1905-1912

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