Abstract

This project is to be led by George Kraus (Ph.D. 1976, Columbia U., Chemistry), chair of the Department of Chemistry at ISU. It is clearly focused on elucidating the chemistry of bioactive components from two widely used genera of herbs, Hypericum and Echinacea. There are four specific aims. To optimize the extraction procedures for these herbs. To fractionate the extracts by a variety of techniques, including GC, LC, capillary electrophoresis, and electrochemical modulated liquid chromatography. Structure determinations will be pursued by Dr. David Wiemer (Ph.D. 1976 in chemistry, U. of Illinois). The synthesis of useful quantities of bioactive compounds will be carried out by George Kraus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES012020-01
Application #
6684244
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2002-07-22
Project End
2007-05-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Iowa State University
Department
Type
DUNS #
City
Ames
State
IA
Country
United States
Zip Code
50011

  Publications

Kraus, George A; Chaudhary, Divya; Riley, Sean et al. (2013) Synthesis of 3-farnesyl salicylic acid, a novel antimicrobial from Piper multiplinervium. Nat Prod Commun 8:911-3
Huang, Nan; Singh, Navrozedeep; Yoon, Kyoungjin et al. (2013) The immuno-regulatory impact of orally-administered Hypericum perforatum extract on Balb/C mice inoculated with H1n1 influenza A virus. PLoS One 8:e76491
Crispin, Matthew C; Hur, Manhoi; Park, Taeseong et al. (2013) Identification and biosynthesis of acylphloroglucinols in Hypericum gentianoides. Physiol Plant 148:354-70
Feng, Yaping; Hurst, Jonathan; Almeida-De-Macedo, Marcia et al. (2012) Massive human co-expression network and its medical applications. Chem Biodivers 9:868-87
Ravven, Simha E; Zimmerman, M Bridget; Schultz, Susan K et al. (2011) 12-month herbal medicine use for mental health from the national Comorbidity Survey Replication (NCS-R). Ann Clin Psychiatry 23:83-94
Qiang, Zhiyi; Ye, Zhong; Hauck, Cathy et al. (2011) Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers. J Ethnopharmacol 137:1107-12
Hammer, Kimberly D P; Yum, Man-Yu; Dixon, Philip M et al. (2010) Identification of JAK-STAT pathways as important for the anti-inflammatory activity of a Hypericum perforatum fraction and bioactive constituents in RAW 264.7 mouse macrophages. Phytochemistry 71:716-25
Senchina, David S; Martin, Aisha E; Buss, Janice E et al. (2010) Effects of Echinacea extracts on macrophage antiviral activities. Phytother Res 24:810-6
Nisly, Nicole L; Gryzlak, Brian M; Zimmerman, M Bridget et al. (2010) Dietary supplement polypharmacy: an unrecognized public health problem? Evid Based Complement Alternat Med 7:107-13
Wu, Lankun; Rowe, Eric W; Jeftinija, Ksenija et al. (2010) Echinacea-induced cytosolic Ca2+ elevation in HEK293. BMC Complement Altern Med 10:72

Showing the most recent 10 out of 62 publications