Abstract

Aims: 1) Evaluation of the effects of Echinacea and Hypericum in animal models: non-specific and specific immune responses to herpes simplex-1 virus, inflammation and cell proliferation. 2) Explore the mechanisms of action of the above using cell culture systems 3) Evaluate the bioavailability of constituents of Hypericum (hypericin, pseudohypericin) and Echinacea (alkylamides, echinacoside). Researchers on this project include Diane Birt as the PI and 5 co-PI's (Susan Carpenter, Joan Cunnick, Suzanne Hendrich, Marian Kohut and Patricia Murphy). The bulk of the work will be done by two assistant scientists and one associate scientist. This project includes in vitro, in vivo and human studies. Facilities for this project are located in several buildings on the Iowa State University Campus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES012020-01
Application #
6684247
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2002-07-22
Project End
2007-05-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Iowa State University
Department
Type
DUNS #
City
Ames
State
IA
Country
United States
Zip Code
50011

  Publications

Crispin, Matthew C; Hur, Manhoi; Park, Taeseong et al. (2013) Identification and biosynthesis of acylphloroglucinols in Hypericum gentianoides. Physiol Plant 148:354-70
Kraus, George A; Chaudhary, Divya; Riley, Sean et al. (2013) Synthesis of 3-farnesyl salicylic acid, a novel antimicrobial from Piper multiplinervium. Nat Prod Commun 8:911-3
Huang, Nan; Singh, Navrozedeep; Yoon, Kyoungjin et al. (2013) The immuno-regulatory impact of orally-administered Hypericum perforatum extract on Balb/C mice inoculated with H1n1 influenza A virus. PLoS One 8:e76491
Feng, Yaping; Hurst, Jonathan; Almeida-De-Macedo, Marcia et al. (2012) Massive human co-expression network and its medical applications. Chem Biodivers 9:868-87
Ravven, Simha E; Zimmerman, M Bridget; Schultz, Susan K et al. (2011) 12-month herbal medicine use for mental health from the national Comorbidity Survey Replication (NCS-R). Ann Clin Psychiatry 23:83-94
Qiang, Zhiyi; Ye, Zhong; Hauck, Cathy et al. (2011) Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers. J Ethnopharmacol 137:1107-12
Hammer, Kimberly D P; Yum, Man-Yu; Dixon, Philip M et al. (2010) Identification of JAK-STAT pathways as important for the anti-inflammatory activity of a Hypericum perforatum fraction and bioactive constituents in RAW 264.7 mouse macrophages. Phytochemistry 71:716-25
Senchina, David S; Martin, Aisha E; Buss, Janice E et al. (2010) Effects of Echinacea extracts on macrophage antiviral activities. Phytother Res 24:810-6
Nisly, Nicole L; Gryzlak, Brian M; Zimmerman, M Bridget et al. (2010) Dietary supplement polypharmacy: an unrecognized public health problem? Evid Based Complement Alternat Med 7:107-13
Wu, Lankun; Rowe, Eric W; Jeftinija, Ksenija et al. (2010) Echinacea-induced cytosolic Ca2+ elevation in HEK293. BMC Complement Altern Med 10:72

Showing the most recent 10 out of 62 publications