The Administrative Core of 'Lipid Peroxidation and Antioxidant Mechanisms' provides scientific andadministrative direction for all aspects of the Program Project. Ned A. Porter, Ph. D. will head the Core. Hewill be aided by an Office Assistant, Ms. Marianne Beebe. This Core provides essential administrativeservices for the overall grant. Ms. Beebe will give priority to preparation of fiscal and technical reports,working with the accounting offices in the College of Arts and Science and the School of Medicine. The Corewill prepare and assemble materials required for the annual progress reports and will ensure all additionalNIEHS and institutional reporting requirements concerning the Program's activities are fulfilled in a timelymanner. Ms. Beebe schedules monthly Program Project Research Meetings for all participants. A'presenter' from each Project provides updates on the ongoing science in their particular project at thesemeetings. Ms. Beebe also schedules bimonthly P.I. Strategy and Tactics meetings and a monthly campuswideForum on Oxidative Injury. Ms. Beebe makes arrangements for the annual External Advisory BoardMeeting. All of the Board members are eminent scholars who have expertise in the general area of researchof the Program Project. Two Vanderbilt University Internal Advisors, Carmelo Rizzo, and F. PeterGuengerich meet regularly with members of the Program Project. Both Advisors have active researchlaboratories and extensive experience with NIEHS supported programs. The Administrative Core alsoutilizes a Program Project Biostatistician (Yu Shyr, Ph. D.) to help with all of the scientific projects. Dr. Shyris an internationally known expert in the field and is a Professor of Preventive Medicine at Vanderbilt.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
2P01ES013125-04
Application #
7540269
Study Section
Special Emphasis Panel (ZES1-TN-D (PO))
Project Start
2008-09-15
Project End
2013-06-30
Budget Start
2008-09-15
Budget End
2009-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$53,693
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Lizama-Manibusan, Britney N; Klein, Sharon; McKenzie, Jennifer R et al. (2016) Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures. ACS Chem Neurosci 7:1188-91
Camarillo, Jeannie M; Rose, Kristie L; Galligan, James J et al. (2016) Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression. Chem Res Toxicol 29:323-32
Pfeffer, Bruce A; Xu, Libin; Porter, Ned A et al. (2016) Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density. Exp Eye Res 145:297-316
Codreanu, S G; Liebler, D C (2015) Novel approaches to identify protein adducts produced by lipid peroxidation. Free Radic Res 49:881-7
Xu, Libin; Kliman, Michal; Forsythe, Jay G et al. (2015) Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI. J Am Soc Mass Spectrom 26:924-33
Aluise, Christopher D; Camarillo, Jeannie M; Shimozu, Yuki et al. (2015) Site-specific, intramolecular cross-linking of Pin1 active site residues by the lipid electrophile 4-oxo-2-nonenal. Chem Res Toxicol 28:817-27
Mathews, Thomas P; Hill, Salisha; Rose, Kristie L et al. (2015) Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas. ACS Chem Biol 10:1258-68
Ren, Jihui; Pei-Chen Lin, Coney; Pathak, Manish C et al. (2014) A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Mol Biol Cell 25:712-27
Bruntz, Ronald C; Taylor, Harry E; Lindsley, Craig W et al. (2014) Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells. J Biol Chem 289:600-16
Bruntz, Ronald C; Lindsley, Craig W; Brown, H Alex (2014) Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev 66:1033-79

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