Although mouse allergen and pollutant exposures have been linked to asthma morbidity in poor minority populations, these factors do not account for most of the observed morbidity, so that additional environmental factors almost certainly contribute to asthma morbidity in this population. One intriguing environmental factor is diet since the population that is most affected by asthma morbidity and mortalitypoor, predominantly African American populations- have a """"""""Western style"""""""" diet that is low in anti-oxidant foods and high in saturated fats. The ASTHMA-DIET Program's overall hypothesis is that a low antioxidant, pro-inflammatory diet impairs the capacity to respond to oxidative stressors, thereby increasing susceptibility to pollutant and mouse allergen exposure. The Data Management and Statistics Core (DMSC) will support the conduct of Projects 1, 2, and 3 of the ASTHMA-DIET Program. Specifically, the DMSC will develop recruitment and study subject tracking tools, data collection tools, and data management systems for the projects. The support services include data quality control/quality assurance, development of randomization schemes, and environmental and biologic specimen tracking. The DMSC will also conduct statistical analyses - from exploratory and interim analyses to final complex multivariate modeling under the direction of the senior biostatistician and Core Co-Leader. The DMSC also supports generation of abstracts and manuscripts. To facilitate interactions between the Environmental Assessment Core and the Projects, the DMSC manages a web-based data portal to facilitate quality control and transfer of environmental assay data to the DMSC. These activities to facilitate interactions will be expanded to include a bar-coding based sample tracking system that will be integrated with Project 3, which will support the conduct of the biomarker assays for Projects 1 and 2. The DMSC holds weekly Center-wide Data Management meetings to review current issues pertaining to any of its support activities. The DMSC serves a key support role, managing a very large amount of complex data which spans the spectrum from questionnaire data, clinical data, environmental exposure data, and biomarker data. The data management system serves to ensure integration of all Projects.

Public Health Relevance

The DMSC serves a key support role, managing a very large amount of complex data from multiple studies These data span the spectrum from questionnaire data, clinical data, environmental exposure data, and biomarker data. The DMSC serves to ensure integration of all Projects.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
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Special Emphasis Panel (ZES1-LKB-G)
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Johns Hopkins University
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Wu, Tianshi David; Eakin, Michelle N; Rand, Cynthia S et al. (2018) In-Home Secondhand Smoke Exposure Among Urban Children With Asthma: Contrasting Households With and Without Residential Smokers. J Public Health Manag Pract :
Rice, Jessica L; Brigham, Emily; Dineen, Rebecca et al. (2018) The feasibility of an air purifier and secondhand smoke education intervention in homes of inner city pregnant women and infants living with a smoker. Environ Res 160:524-530
Wu, Tianshi David; Brigham, Emily P; Peng, Roger et al. (2018) Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children. J Allergy Clin Immunol Pract 6:2157-2159.e5
Paulin, Laura M; Williams, D 'Ann L; Peng, Roger et al. (2017) 24-h Nitrogen dioxide concentration is associated with cooking behaviors and an increase in rescue medication use in children with asthma. Environ Res 159:118-123
Grant, Torie; Aloe, Charles; Perzanowski, Matthew et al. (2017) Mouse Sensitization and Exposure Are Associated with Asthma Severity in Urban Children. J Allergy Clin Immunol Pract 5:1008-1014.e1
McCormack, Meredith C; Paulin, Laura M; Gummerson, Christine E et al. (2017) Colder temperature is associated with increased COPD morbidity. Eur Respir J 49:
Peters, Kamau O; Williams, D' Ann L; Abubaker, Salahadin et al. (2017) Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children. J Expo Sci Environ Epidemiol 27:290-298
Nnodum, Benedicta Nneoma; McCormack, Meredith C; Putcha, Nirupama et al. (2017) Impact of Physical Activity on Reporting of Childhood Asthma Symptoms. Lung 195:693-698
Kolahdooz, Fariba; Butler, Jennie L; Christiansen, Karina et al. (2016) Food and Nutrient Intake in African American Children and Adolescents Aged 5 to 16 Years in Baltimore City. J Am Coll Nutr 35:205-16
McCormack, Meredith C; Belli, Andrew J; Waugh, Darryn et al. (2016) Respiratory Effects of Indoor Heat and the Interaction with Air Pollution in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 13:2125-2131

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