Abstract

Public Health Relevance

Respiratory conditions in children are a serious public health concern throughout the world. Asthma is the most common chronic childhood disease, affecting 9 million children in the U.S. This disease is increasing in prevalence, incidence, and severity, particularly in developed countries. Air pollution accounts for substantial morbidity and mortality in children. The overall goal of this project is to understand how and why air pollution alters lung host defense and places children at risk of developing lung infections and asthma.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES018181-01
Application #
7855087
Study Section
Special Emphasis Panel (ZES1-LKB-G (P1))
Project Start
Project End
Budget Start
2009-09-25
Budget End
2010-07-31
Support Year
1
Fiscal Year
2009
Total Cost
$375,281
Indirect Cost

  Institution

Name
National Jewish Health
Department
Type
DUNS #
076443019
City
Denver
State
CO
Country
United States
Zip Code
80206

  Publications

Dutmer, Cullen M; Schiltz, Allison M; Freeman, Kristy L et al. (2018) Observed Home Dampness and Mold Are Associated with Sustained Spikes in Personal Exposure to Particulate Matter Less than 10 ?m in Diameter in Exacerbation-Prone Children with Asthma. Ann Am Thorac Soc 15:S131-S132
Yang, Ivana V; Richards, Adam; Davidson, Elizabeth J et al. (2017) The Nasal Methylome: A Key to Understanding Allergic Asthma. Am J Respir Crit Care Med 195:829-831
Yang, Ivana V; Pedersen, Brent S; Liu, Andrew H et al. (2017) The nasal methylome and childhood atopic asthma. J Allergy Clin Immunol 139:1478-1488
Breton, Carrie V; Marsit, Carmen J; Faustman, Elaine et al. (2017) Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect 125:511-526
Alper, Scott; Warg, Laura A; De Arras, Lesly et al. (2016) Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria. Genetics 204:327-36
Dakhama, Azzeddine; Gelfand, Erwin W (2016) In Vivo Assessment of Airway Function in the Mouse Model. Methods Mol Biol 1442:219-30
Szefler, Stanley J (2015) Advances in pediatric asthma in 2014: Moving toward a population health perspective. J Allergy Clin Immunol 135:644-52
Davis, Meghan F; Peng, Roger D; McCormack, Meredith C et al. (2015) Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults. J Allergy Clin Immunol 135:811-3.e5
Julian, Colleen G; Pedersen, Brent S; Salmon, Carlos Salinas et al. (2015) Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy. Clin Transl Sci 8:740-5
Liang, Liming; Willis-Owen, Saffron A G; Laprise, Catherine et al. (2015) An epigenome-wide association study of total serum immunoglobulin E concentration. Nature 520:670-674

Showing the most recent 10 out of 33 publications