The overall goal of our Children's Environmental Health Center (CEHC) application is to evaluate the impact of environmental exposures, specifically air pollution and endotoxin, on response to viral infection and allergen exposure in children. The Community Outreach and Translation Core (COTC) will serve as a forum for exchanging ideas, thoughts and information regarding the impact of the environment on the respiratory health of children in urban and rural Colorado. The COTC will be a bridge between scientific investigators and community stakeholders for organizing approaches and strategies for translation and uptake by community members. The COTC will assimilate the available research evidence while informing the CEHC research investigators of the need for responsive research to the community. Initially our work in developing this model will center on asthma in Denver and select rural communities and then extend to other respiratory illnesses, and other communities in Colorado.
Our specific aims i nclude the following: 1. To develop a strong COTC that is informed by the Community Advisory Board (CAB) and accomplishes its work through following the principles of community based participatory research, community engagement and knowledge translation and disseminafion. 2. To be responsive to the needs of the community, the CEHC through the COTC will compile existing research evidence related to factors that impact respiratory health of children in Colorado that will be used to inform the work of community stakeholders, such as policies, regulations, and programs. 3. The CAB will assist with the interpretafion and key messaging of the CEHCs research as well as informing the strategies for community dissemination and uptake. 4. To leverage existing community infrastructures and partnerships to permit the piloting of translation and implementation strategies that will identify the most effective strategies resulting in the uptake of research in communities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES018181-02
Application #
8185128
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
2
Fiscal Year
2010
Total Cost
$154,441
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
076443019
City
Denver
State
CO
Country
United States
Zip Code
80206
Dutmer, Cullen M; Schiltz, Allison M; Freeman, Kristy L et al. (2018) Observed Home Dampness and Mold Are Associated with Sustained Spikes in Personal Exposure to Particulate Matter Less than 10 ?m in Diameter in Exacerbation-Prone Children with Asthma. Ann Am Thorac Soc 15:S131-S132
Yang, Ivana V; Richards, Adam; Davidson, Elizabeth J et al. (2017) The Nasal Methylome: A Key to Understanding Allergic Asthma. Am J Respir Crit Care Med 195:829-831
Yang, Ivana V; Pedersen, Brent S; Liu, Andrew H et al. (2017) The nasal methylome and childhood atopic asthma. J Allergy Clin Immunol 139:1478-1488
Breton, Carrie V; Marsit, Carmen J; Faustman, Elaine et al. (2017) Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect 125:511-526
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Dakhama, Azzeddine; Gelfand, Erwin W (2016) In Vivo Assessment of Airway Function in the Mouse Model. Methods Mol Biol 1442:219-30
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Davis, Meghan F; Peng, Roger D; McCormack, Meredith C et al. (2015) Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults. J Allergy Clin Immunol 135:811-3.e5
Julian, Colleen G; Pedersen, Brent S; Salmon, Carlos Salinas et al. (2015) Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy. Clin Transl Sci 8:740-5
Liang, Liming; Willis-Owen, Saffron A G; Laprise, Catherine et al. (2015) An epigenome-wide association study of total serum immunoglobulin E concentration. Nature 520:670-674

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