Abstract

Specific Aims: Research Project 2 tests the hypotheses that polybrominated diphenyl ethers (PBDEs), perfluorinated chemicals (PFCs) and environmental organic acids (EOAs) accumulate differently in human fetuses than in pregnant women during mid-gestation, and that these chemical exposures negatively impact placental development and function, important outcomes that can adversely affect in utero growth and development. Accordingly, the goal is to compare 2nd trimester maternal serum, placenta and fetal liver levels of PBDEs, PFCs and select EOAs through traditional and novel biomonitoring approaches (Aim 1); and evaluate the relationship between these chemical exposures and disruptions of placental development by analyzing morphological and molecular markers of trophoblast differentiation and function (Aim 2).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES022841-05
Application #
9320030
Study Section
Special Emphasis Panel (ZES1-LKB-K)
Project Start
Project End
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
5
Fiscal Year
2017
Total Cost
$140,891
Indirect Cost
$25,144

  Institution

Name
University of California San Francisco
Department
Type
Domestic Higher Education
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118

  Publications

Wang, Aolin; Gerona, Roy R; Schwartz, Jackie M et al. (2018) A Suspect Screening Method for Characterizing Multiple Chemical Exposures among a Demographically Diverse Population of Pregnant Women in San Francisco. Environ Health Perspect 126:077009
Varshavsky, Julia R; Morello-Frosch, Rachel; Woodruff, Tracey J et al. (2018) Dietary sources of cumulative phthalates exposure among the U.S. general population in NHANES 2005-2014. Environ Int 115:417-429
Huang, Hongtai; Wang, Aolin; Morello-Frosch, Rachel et al. (2018) Cumulative Risk and Impact Modeling on Environmental Chemical and Social Stressors. Curr Environ Health Rep 5:88-99
Gerona, Roy R; Schwartz, Jackie M; Pan, Janet et al. (2018) Suspect screening of maternal serum to identify new environmental chemical biomonitoring targets using liquid chromatography-quadrupole time-of-flight mass spectrometry. J Expo Sci Environ Epidemiol 28:101-108
Zota, Ami R; Mitro, Susanna D; Robinson, Joshua F et al. (2018) Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression. Environ Int 112:269-278
Koman, Patricia D; Hogan, Kelly A; Sampson, Natalie et al. (2018) Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining ""At-Risk"" Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy. World Med Health Policy 10:7-54
Casey, Joan A; Gemmill, Alison; Karasek, Deborah et al. (2018) Increase in fertility following coal and oil power plant retirements in California. Environ Health 17:44
Casey, Joan A; Karasek, Deborah; Ogburn, Elizabeth L et al. (2018) Coal and oil power plant retirements in California associated with reduced preterm birth among populations nearby. Am J Epidemiol :
Lam, Juleen; Lanphear, Bruce P; Bellinger, David et al. (2017) Developmental PBDE Exposure and IQ/ADHD in Childhood: A Systematic Review and Meta-analysis. Environ Health Perspect 125:086001
Robinson, Joshua F; Kapidzic, Mirhan; Gormley, Matthew et al. (2017) Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology 158:1581-1594

Showing the most recent 10 out of 22 publications