Abstract

Specific Aims: This project will test the hypothesis that prenatal exposures to endocrine disrupting chemicals (EDCs) affect fetal growth?specifically birth weight and whether the infant is small for gestational age (SGA) at delivery?and that these adverse effects are magnified by chronic psychosocial stress. We will focus on two groups of EDCs?polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs)?and measures of chronic psychosocial stress. First, we will evaluate the relationship between prenatal PBDE and PFC exposures and adverse birth weight outcomes (Aim 1). We will then integrate place based, perceptual, and biological measures of stress in the maternal-fetal unit to characterize chronic psychosocial stress during pregnancy and assess birth weight effects (Aim 2). Lastly, we will examine potential interactive effects of EDC and chronic psychosocial stress exposures on birth weight outcomes (Aim 3).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
3P01ES022841-05S1
Application #
9688772
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Gray, Kimberly A
Project Start
Project End
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118

  Publications

Wang, Aolin; Gerona, Roy R; Schwartz, Jackie M et al. (2018) A Suspect Screening Method for Characterizing Multiple Chemical Exposures among a Demographically Diverse Population of Pregnant Women in San Francisco. Environ Health Perspect 126:077009
Varshavsky, Julia R; Morello-Frosch, Rachel; Woodruff, Tracey J et al. (2018) Dietary sources of cumulative phthalates exposure among the U.S. general population in NHANES 2005-2014. Environ Int 115:417-429
Huang, Hongtai; Wang, Aolin; Morello-Frosch, Rachel et al. (2018) Cumulative Risk and Impact Modeling on Environmental Chemical and Social Stressors. Curr Environ Health Rep 5:88-99
Gerona, Roy R; Schwartz, Jackie M; Pan, Janet et al. (2018) Suspect screening of maternal serum to identify new environmental chemical biomonitoring targets using liquid chromatography-quadrupole time-of-flight mass spectrometry. J Expo Sci Environ Epidemiol 28:101-108
Zota, Ami R; Mitro, Susanna D; Robinson, Joshua F et al. (2018) Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression. Environ Int 112:269-278
Koman, Patricia D; Hogan, Kelly A; Sampson, Natalie et al. (2018) Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining ""At-Risk"" Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy. World Med Health Policy 10:7-54
Casey, Joan A; Gemmill, Alison; Karasek, Deborah et al. (2018) Increase in fertility following coal and oil power plant retirements in California. Environ Health 17:44
Casey, Joan A; Karasek, Deborah; Ogburn, Elizabeth L et al. (2018) Coal and oil power plant retirements in California associated with reduced preterm birth among populations nearby. Am J Epidemiol :
Lam, Juleen; Lanphear, Bruce P; Bellinger, David et al. (2017) Developmental PBDE Exposure and IQ/ADHD in Childhood: A Systematic Review and Meta-analysis. Environ Health Perspect 125:086001
Robinson, Joshua F; Kapidzic, Mirhan; Gormley, Matthew et al. (2017) Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology 158:1581-1594

Showing the most recent 10 out of 22 publications