Abstract

The CORE laboratory provides facilities to all members of the Yale Center for Structural Biology for the investigation of macromolecular systems by X-ray crystallography and X-ray small-angle scattering, including both instruments for data collection, and computers for data reduction and analysis. Among the computers available are several molecular graphics systems, which are vital to the activities of all users. The staff of the CORE laboratory maintains and upgrades CSB instrumentation, and assists users with data collection and analysis. The CORE staff also maintains the CSB website, which is heavily used by structural biologist both inside and outside Yale. This invaluable resource provides its users with access to all the programs and data bases that are generally useful to structural biologists. The programs on the web site are upgraded as new releases appear, and documentation is provided for many of them to further assist users.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM022778-33
Application #
7591165
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
33
Fiscal Year
2008
Total Cost
$291,253
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Wang, Jimin; Liu, Zheng; Crabtree, Robert H et al. (2018) On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation. Protein Sci 27:2051-2061
Sherlock, Madeline E; Sadeeshkumar, Harini; Breaker, Ronald R (2018) Variant Bacterial Riboswitches Associated with Nucleotide Hydrolase Genes Sense Nucleoside Diphosphates. Biochemistry :
Harris, Kimberly A; Zhou, Zhiyuan; Peters, Michelle L et al. (2018) A second RNA-binding protein is essential for ethanol tolerance provided by the bacterial OLE ribonucleoprotein complex. Proc Natl Acad Sci U S A 115:E6319-E6328
Greenlee, Etienne B; Stav, Shira; Atilho, Ruben M et al. (2018) Challenges of ligand identification for the second wave of orphan riboswitch candidates. RNA Biol 15:377-390
Mirihana Arachchilage, Gayan; Sherlock, Madeline E; Weinberg, Zasha et al. (2018) SAM-VI RNAs selectively bind S-adenosylmethionine and exhibit similarities to SAM-III riboswitches. RNA Biol 15:371-378
Wang, Jimin (2018) Determination of chemical identity and occupancy from experimental density maps. Protein Sci 27:411-420
Sherlock, Madeline E; Sudarsan, Narasimhan; Breaker, Ronald R (2018) Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems. Proc Natl Acad Sci U S A 115:6052-6057
Harris, Kimberly A; Breaker, Ronald R (2018) Large Noncoding RNAs in Bacteria. Microbiol Spectr 6:
Yang, Yang; Kang, Dongwei; Nguyen, Laura A et al. (2018) Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife 7:
Nelson, James W; Breaker, Ronald R (2017) The lost language of the RNA World. Sci Signal 10:

Showing the most recent 10 out of 143 publications