Abstract

This project aims at increasing knowledge of the human genetics map, by collecting collaboratively information with new (and old) markers on a selected sample of pedigrees and nuclear families. New markers are provided by DNA probes, in part random and in part corresponding to known genes; and also by monoclonal antibodies against specific proteins. Among classes of genes that are particularly investigated are: immunoglobulin heavy chain genes (and proteins); leukocyte membrane antigens; nuclear genes determining mitochondrial proteins, and several others. Blood samples are being collected locally, and also in cooperation with other laboratories which already have collected, or are interested in collecting, blood samples from families that are satisfactory for linkage purposes, and these are or will be typed for classical genetic markers. All information will be centralized on a computer and analyzed for gene frequency segregation, linkage and other aspects of genetic interest. Comparisons between genetic, cytological and deletion maps will be carried out. It is expected that the project will continue producing new markers of interest for a variety of purposes, ranging from the study of the human genetic map, to those of association with diseases and of population genetics.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
2P01GM028428-09
Application #
3096089
Study Section
(SSS)
Project Start
1980-05-01
Project End
1993-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Jobin, Matthew J; Mountain, Joanna L (2008) REJECTOR: software for population history inference from genetic data via a rejection algorithm. Bioinformatics 24:2936-7
Henn, Brenna M; Gignoux, Christopher; Lin, Alice A et al. (2008) Y-chromosomal evidence of a pastoralist migration through Tanzania to southern Africa. Proc Natl Acad Sci U S A 105:10693-8
Gross, Eva; Holzl, Georg; Arnold, Norbert et al. (2007) Allelic loss analysis by denaturing high-performance liquid chromatography and electrospray ionization mass spectrometry. Hum Mutat 28:303-11
David, Lior; Rosenberg, Noah A; Lavi, Uri et al. (2007) Genetic diversity and population structure inferred from the partially duplicated genome of domesticated carp, Cyprinus carpio L. Genet Sel Evol 39:319-40
Tishkoff, Sarah A; Gonder, Mary Katherine; Henn, Brenna M et al. (2007) History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation. Mol Biol Evol 24:2180-95
Belle, Elise M S; Ramakrishnan, Uma; Mountain, Joanna L et al. (2006) Serial coalescent simulations suggest a weak genealogical relationship between Etruscans and modern Tuscans. Proc Natl Acad Sci U S A 103:8012-7
Sella, Guy; Ardell, David H (2006) The coevolution of genes and genetic codes: Crick's frozen accident revisited. J Mol Evol 63:297-313
Sutton, Wesley K; Knight, Alec; Underhill, Peter A et al. (2006) Toward resolution of the debate regarding purported crypto-Jews in a Spanish-American population: evidence from the Y chromosome. Ann Hum Biol 33:100-11
Greely, Henry T; Riordan, Daniel P; Garrison, Nanibaa' A et al. (2006) Family ties: the use of DNA offender databases to catch offenders' kin. J Law Med Ethics 34:248-62
Kivisild, Toomas; Shen, Peidong; Wall, Dennis P et al. (2006) The role of selection in the evolution of human mitochondrial genomes. Genetics 172:373-87

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