The central goals of this proposal concern the relationship between protein structure and protein function. The powerful techniques of recombinant DNA technology will be applied by four investigators to study distinct groups of biologically important macromolecules. Most of these molecules are involved in cell-cell communication and in most instances, DNA probes are available to allow a more global approach to a full appreciation of the synthesis, expression and activity of a particular protein. The Program Project mechanism is requested as the technologies required to carry out each individual project require not only the intense intellectual interaction presently taking place, but, in addition, the pooling of resources and equipment. All the studies largely involve protocols in the mouse and rat, although the results of these projects will have clear applications to man.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM031689-07
Application #
3096165
Study Section
Special Emphasis Panel (SSS (C))
Project Start
1984-04-01
Project End
1994-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
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