Abstract

The Division of Neurobiology and Behavior consists of seven independent laboratories: Mammalian neurophysiology, invertebrate neurobiology, neuropsychology, neurochemistry, biophysics, developmental neurobiology and morphology. The research of the Division is directed toward cellular analyses of behavior in selected vertebrates and in Aplysia. Because the brains of higher mammals contain trillions of nerve cells and the simplest behaviors involve actions of diverse cells with complex interconnections, our approach has been to reduce experimental preparations to manageable proportions. In mammals, complexity has been simplified by selecting particular brain systems for study. Thus, voluntary movements that depend on sensory clues being transformed into motor movement in just a few synaptic relays. In Aplysia, even complex behavior is mediated by only a small number of neurons. Because many of these cells can be identified individually by electrophysiological biochemical and morphological techniques, it is possible to correlate behavior and learning with neural function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM032099-04
Application #
3096171
Study Section
(SSS)
Project Start
1982-05-01
Project End
1987-04-30
Budget Start
1985-05-01
Budget End
1987-04-30
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Tang, D; Goldberg, D J (2000) Bundling of microtubules in the growth cone induced by laminin. Mol Cell Neurosci 15:303-13
Rosen, S C; Miller, M W; Cropper, E C et al. (2000) Outputs of radula mechanoafferent neurons in Aplysia are modulated by motor neurons, interneurons, and sensory neurons. J Neurophysiol 83:1621-36
Rosen, S C; Miller, M W; Evans, C G et al. (2000) Diverse synaptic connections between peptidergic radula mechanoafferent neurons and neurons in the feeding system of Aplysia. J Neurophysiol 83:1605-20
Chain, D G; Casadio, A; Schacher, S et al. (1999) Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22:147-56
Baranes, D; Lederfein, D; Huang, Y Y et al. (1998) Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway. Neuron 21:813-25
Sun, Z Y; Schacher, S (1998) Binding of serotonin to receptors at multiple sites is required for structural plasticity accompanying long-term facilitation of Aplysia sensorimotor synapses. J Neurosci 18:3991-4000
Grabham, P W; Goldberg, D J (1997) Nerve growth factor stimulates the accumulation of beta1 integrin at the tips of filopodia in the growth cones of sympathetic neurons. J Neurosci 17:5455-65
Bailey, C H; Kaang, B K; Chen, M et al. (1997) Mutation in the phosphorylation sites of MAP kinase blocks learning-related internalization of apCAM in Aplysia sensory neurons. Neuron 18:913-24
Martin, K C; Casadio, A; Zhu, H et al. (1997) Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell 91:927-38
Zhu, H; Wu, F; Schacher, S (1997) Site-specific and sensory neuron-dependent increases in postsynaptic glutamate sensitivity accompany serotonin-induced long-term facilitation at Aplysia sensorimotor synapses. J Neurosci 17:4976-86

Showing the most recent 10 out of 96 publications