Population Genetics of Sod, Adh, and Gpdh

Hudson, Richard R.

Abstract

This project seeks to ascertain the amount and geographic distribution of genetic variation at the DNA level in three Drosophila species at three loci. It also seeks to determine what forces are most important in generating and maintaining the genetic variation in these populations. Understanding the genetic variation with Drosophila species also be applicable to studying human genetic variation. Ten to twenty copies of SOD, ADH, and Gpdh will be sequenced from different localities in D. melanogaster, D. simulans, and D. willistoni. Mutation parameters, migration parameters and recombination parameters will be estimated. The possibility of selectively maintained polymorphisms and recent selective substitutions will be tested by several statistical techniques, using within species variation and between species comparisons of DNA sequences.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Program Projects (P01)
• Project #: 5P01GM042397-02
• Application #: 3842123
• Support Year: 2
• Fiscal Year: 1992

Institution

• Name: University of California Irvine
• DUNS #: 161202122
• City: Irvine
• State: CA
• Country: United States
• Zip Code: 92697

Publications

Balakirev, Evgeniy S; Anisimova, Maria; Ayala, Francisco J (2006) Positive and negative selection in the beta-esterase gene cluster of the Drosophila melanogaster subgroup. J Mol Evol 62:496-510

Balakirev, Evgeniy S; Chechetkin, Vladimir R; Lobzin, Vasily V et al. (2005) Entropy and GC Content in the beta-esterase gene cluster of the Drosophila melanogaster subgroup. Mol Biol Evol 22:2063-72

Rodriguez-Trelles, Francisco; Tarrio, Rosa; Ayala, Francisco J (2005) Is ectopic expression caused by deregulatory mutations or due to gene-regulation leaks with evolutionary potential? Bioessays 27:592-601

Balakirev, Evgeniy S; Ayala, Francisco J (2004) The beta-esterase gene cluster of drosophila melanogaster: is psiEst-6 a pseudogene, a functional gene, or both? Genetica 121:165-79

Balakirev, E S; Ayala, F J (2004) [Pseudogenes: structure conservation, expression, and functions] Zh Obshch Biol 65:306-21

Leclerc, M C; Durand, P; Gauthier, C et al. (2004) Meager genetic variability of the human malaria agent Plasmodium vivax. Proc Natl Acad Sci U S A 101:14455-60

Balakirev, Evgeniy S; Ayala, Francisco J (2004) Nucleotide variation in the tinman and bagpipe homeobox genes of Drosophila melanogaster. Genetics 166:1845-56

Saenz-de-Miera, L E; Ayala, F J (2004) Complex evolution of orthologous and paralogous decarboxylase genes. J Evol Biol 17:55-66

Haag, K L; Alves-Junior, L; Zaha, A et al. (2004) Contingent, non-neutral evolution in a multicellular parasite: natural selection and gene conversion in the Echinococcus granulosus antigen B gene family. Gene 333:157-67

Arend, A C; Zaha, A; Ayala, F J et al. (2004) The Echinococcus granulosus antigen B shows a high degree of genetic variability. Exp Parasitol 108:76-80