Abstract

This application is for a Program Project for broadly based research in statistical and quantitative genetics. The program will support research of personnel in the Departments of Statistics, Genetics and Crop Science at North Carolina State University. Consortium arrangements are proposed with the University of California at Davis, the University of California at Riverside, Dalhousie University, and the University of Minnesota. Theoretical research will be concerned with statistical aspects of using molecular genetic data to construct evolutionary histories, and in determining the effects of mutation on quantitative characters. Methods for constructing evolutionary trees will be applied to some chloroplast DNA sequences from a range of plant species. Quantitative genetic studies in Drosophila will focus on the effects of transposable element induced mutation on bristle numbers. Work on mice will consider the quantitative genetic aspects of developmental change in cranofacial structure. Restriction to recombination as a possible isolating mechanism for the evolutionary divergence of races of maize and teosinte will be studied using isozyme marker stocks. Both isozyme and RFLP markers will be employed in searches for genes affecting components of yield in maize.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM045344-03
Application #
3096414
Study Section
Genetics Study Section (GEN)
Project Start
1990-12-01
Project End
1995-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
North Carolina State University Raleigh
Department
Type
Schools of Arts and Sciences
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695

  Publications

Bryant, David; Bouckaert, Remco; Felsenstein, Joseph et al. (2012) Inferring species trees directly from biallelic genetic markers: bypassing gene trees in a full coalescent analysis. Mol Biol Evol 29:1917-32
RoyChoudhury, Arindam; Thompson, Elizabeth A (2012) Ascertainment correction for a population tree via a pruning algorithm for likelihood computation. Theor Popul Biol 82:59-65
Beecham, Gary W; Weir, Bruce S (2011) Confidence interval of the likelihood ratio associated with mixed stain DNA evidence. J Forensic Sci 56 Suppl 1:S166-71
Magwire, Michael M; Yamamoto, Akihiko; Carbone, Mary Anna et al. (2010) Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. PLoS Genet 6:e1001037
Gao, Xiaoyi; Martin, Eden R (2009) Using allele sharing distance for detecting human population stratification. Hum Hered 68:182-91
Fernandes, Andrew D; Atchley, William R (2008) Biochemical and functional evidence of p53 homology is inconsistent with molecular phylogenetics for distant sequences. J Mol Evol 67:51-67
Nielsen, Dahlia M; Suchindran, Sunil; Smith, Christopher P (2008) Does strong linkage disequilibrium guarantee redundant association results? Genet Epidemiol 32:546-52
Funk-Keenan, Jhondra; Haire, Frances; Woolard, Sara et al. (2008) Hepatic endopolyploidy as a cellular consequence of age-specific selection for rate of development in mice. J Exp Zool B Mol Dev Evol 310:385-97
Kim, Yunjung; Feng, Sheng; Zeng, Zhao-Bang (2008) Measuring and partitioning the high-order linkage disequilibrium by multiple order Markov chains. Genet Epidemiol 32:301-12
Fernandes, Andrew D; Atchley, William R (2008) Site-specific evolutionary rates in proteins are better modeled as non-independent and strictly relative. Bioinformatics 24:2177-83

Showing the most recent 10 out of 69 publications