Abstract

The aim of this proposal is to establish Drosophila as a model system for quantitative genetic dissection of complex neurotransmitter-modulated traits.
The specific aims of this proposal are to: Use linkage disequilibrium mapping to screen for associations between SNPs in monoamine receptor and enzyme loci, and five phenotypes: prenupal heart rate, and the reflex behaviors grooming, grasping, quivering and self- Assess the repeatability of association studies suing sibship-based statistical designs. Characterize the mutational distribution due to single P-element transposable element insertions affecting tyrosine- and dopa- decarboxylase activity, and identify up to 10 insertions that demonstrably affect genes involved in these traits.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
2P01GM045344-11
Application #
6430131
Study Section
Special Emphasis Panel (ZRG1)
Project Start
1990-12-01
Project End
2005-11-30
Budget Start
Budget End
Support Year
11
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
North Carolina State University Raleigh
Department
Type
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695

  Publications

Bryant, David; Bouckaert, Remco; Felsenstein, Joseph et al. (2012) Inferring species trees directly from biallelic genetic markers: bypassing gene trees in a full coalescent analysis. Mol Biol Evol 29:1917-32
RoyChoudhury, Arindam; Thompson, Elizabeth A (2012) Ascertainment correction for a population tree via a pruning algorithm for likelihood computation. Theor Popul Biol 82:59-65
Beecham, Gary W; Weir, Bruce S (2011) Confidence interval of the likelihood ratio associated with mixed stain DNA evidence. J Forensic Sci 56 Suppl 1:S166-71
Magwire, Michael M; Yamamoto, Akihiko; Carbone, Mary Anna et al. (2010) Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. PLoS Genet 6:e1001037
Gao, Xiaoyi; Martin, Eden R (2009) Using allele sharing distance for detecting human population stratification. Hum Hered 68:182-91
Fernandes, Andrew D; Atchley, William R (2008) Biochemical and functional evidence of p53 homology is inconsistent with molecular phylogenetics for distant sequences. J Mol Evol 67:51-67
Nielsen, Dahlia M; Suchindran, Sunil; Smith, Christopher P (2008) Does strong linkage disequilibrium guarantee redundant association results? Genet Epidemiol 32:546-52
Funk-Keenan, Jhondra; Haire, Frances; Woolard, Sara et al. (2008) Hepatic endopolyploidy as a cellular consequence of age-specific selection for rate of development in mice. J Exp Zool B Mol Dev Evol 310:385-97
Kim, Yunjung; Feng, Sheng; Zeng, Zhao-Bang (2008) Measuring and partitioning the high-order linkage disequilibrium by multiple order Markov chains. Genet Epidemiol 32:301-12
Fernandes, Andrew D; Atchley, William R (2008) Site-specific evolutionary rates in proteins are better modeled as non-independent and strictly relative. Bioinformatics 24:2177-83

Showing the most recent 10 out of 69 publications