Abstract

The long-term goal of this project is to understand te genetic basis of quantitative variation in longevity in terms of phenotypic and molecular variation at individual loci, using Drosophila melanogaster as a model system. The immediate goals for this project period are: To identify new candidate genes that increase and decrease adult lifespan, using a screen for P element insertional mutations with quantitative effects on longevity in a highly inbred, on-mutant background. To identify gene regions and genetic loci contributing to naturally occurring variation in longevity, using quantitative complementation to deficiencies and mutations at candidate loci. To use linkage disequilibrium mapping of a large sample of alleles form a randomly mating population to map the QTN (quantitative trait nucleotides) responsible for naturally occurring variation in lifespan.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
2P01GM045344-11
Application #
6410425
Study Section
Project Start
2000-12-25
Project End
2001-11-30
Budget Start
Budget End
Support Year
11
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
North Carolina State University Raleigh
Department
Type
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695

  Publications

Bryant, David; Bouckaert, Remco; Felsenstein, Joseph et al. (2012) Inferring species trees directly from biallelic genetic markers: bypassing gene trees in a full coalescent analysis. Mol Biol Evol 29:1917-32
RoyChoudhury, Arindam; Thompson, Elizabeth A (2012) Ascertainment correction for a population tree via a pruning algorithm for likelihood computation. Theor Popul Biol 82:59-65
Beecham, Gary W; Weir, Bruce S (2011) Confidence interval of the likelihood ratio associated with mixed stain DNA evidence. J Forensic Sci 56 Suppl 1:S166-71
Magwire, Michael M; Yamamoto, Akihiko; Carbone, Mary Anna et al. (2010) Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. PLoS Genet 6:e1001037
Gao, Xiaoyi; Martin, Eden R (2009) Using allele sharing distance for detecting human population stratification. Hum Hered 68:182-91
Funk-Keenan, Jhondra; Haire, Frances; Woolard, Sara et al. (2008) Hepatic endopolyploidy as a cellular consequence of age-specific selection for rate of development in mice. J Exp Zool B Mol Dev Evol 310:385-97
Kim, Yunjung; Feng, Sheng; Zeng, Zhao-Bang (2008) Measuring and partitioning the high-order linkage disequilibrium by multiple order Markov chains. Genet Epidemiol 32:301-12
Fernandes, Andrew D; Atchley, William R (2008) Site-specific evolutionary rates in proteins are better modeled as non-independent and strictly relative. Bioinformatics 24:2177-83
Aylor, David L; Zeng, Zhao-Bang (2008) From classical genetics to quantitative genetics to systems biology: modeling epistasis. PLoS Genet 4:e1000029
Garcia, Antonio Augusto Franco; Wang, Shengchu; Melchinger, Albrecht E et al. (2008) Quantitative trait loci mapping and the genetic basis of heterosis in maize and rice. Genetics 180:1707-24

Showing the most recent 10 out of 69 publications