Abstract

Biological Testing Core. The Biological Testing Core facility will provide the resources to perform behavioral assays and ligand binding assays for the compounds synthesized in the Program. It includes support for the individuals who performs the assays, and supplies for this effort.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
3P01GM047969-07S1
Application #
6296707
Study Section
Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Budelier, Melissa M; Cheng, Wayland W L; Bergdoll, Lucie et al. (2017) Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. J Biol Chem 292:9294-9304
Jiang, Xiaoping; Shu, Hong-Jin; Krishnan, Kathiresan et al. (2016) A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition. Neuropharmacology 108:193-206
Zhou, Yu; Xia, Xiao-Ming; Lingle, Christopher J (2015) Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications. Proc Natl Acad Sci U S A 112:5237-42
Li, Ping; Akk, Gustav (2015) Synaptic-type ?1?2?2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs. Mol Pharmacol 87:776-81
Linsenbardt, Andrew J; Taylor, Amanda; Emnett, Christine M et al. (2014) Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. Neuropharmacology 85:232-42
Jafurulla, Md; Rao, Bhagyashree D; Sreedevi, Sugunan et al. (2014) Stereospecific requirement of cholesterol in the function of the serotonin1A receptor. Biochim Biophys Acta 1838:158-63
Chen, Zi-Wei; Wang, Cunde; Krishnan, Kathiresan et al. (2014) 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology (Berl) 231:3479-91
Mennerick, Steven; Taylor, Amanda A; Zorumski, Charles F (2014) Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function. Psychopharmacology (Berl) 231:3493-501
El Bitar, Fadia; Meunier, Johann; Villard, Vanessa et al. (2014) Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against A?????? peptide-induced toxicity in vitro and in vivo in mice. Psychopharmacology (Berl) 231:3293-3312
Peyrot, Sara M; Nachtergaele, Sigrid; Luchetti, Giovanni et al. (2014) Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. J Biol Chem 289:11095-110

Showing the most recent 10 out of 193 publications