Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
1P01GM062532-01
Application #
6371050
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2000-09-30
Project End
2005-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost
Name
California Institute of Technology
Department
Type
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Elmore, Donald E (2010) Bringing ion channel crystal structures into sharper focus with computer modeling: examples from mechanosensitive channels. Future Med Chem 2:909-13
Maurer, Joshua A; Elmore, Donald E; Clayton, Daniel et al. (2008) Confirming the revised C-terminal domain of the MscL crystal structure. Biophys J 94:4662-7
Maurer, Joshua A; White, Victor E; Dougherty, Dennis A et al. (2007) Reconstitution of ion channels in agarose-supported silicon orifices. Biosens Bioelectron 22:2577-84
Spronk, Steven A; Elmore, Donald E; Dougherty, Dennis A (2006) Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance. Biophys J 90:3555-69
Kochendoerfer, Gerd G; Clayton, Daniel; Becker, Christian (2005) Chemical synthesis approaches to the engineering of ion channels. Protein Pept Lett 12:737-41
Kochendoerfer, Gerd G; Jones, David H; Lee, Sangwon et al. (2004) Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepared by total chemical synthesis. J Am Chem Soc 126:2439-46
Clayton, Daniel; Shapovalov, George; Maurer, Joshua A et al. (2004) Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 101:4764-9
Becker, Christian F W; Strop, Pavel; Bass, Randal B et al. (2004) Conversion of a mechanosensitive channel protein from a membrane-embedded to a water-soluble form by covalent modification with amphiphiles. J Mol Biol 343:747-58
Becker, Christian F W; Clayton, Daniel; Shapovalov, George et al. (2004) On-resin assembly of a linkerless lanthanide(III)-based luminescence label and its application to the total synthesis of site-specifically labeled mechanosensitive channels. Bioconjug Chem 15:1118-24
Shapovalov, George; Lester, Henry A (2004) Gating transitions in bacterial ion channels measured at 3 microns resolution. J Gen Physiol 124:151-61

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