The Biophysics facility has instrumentation for analytical ultracentrifugation, microcalorimetery, CD, etc., as well as a Protein Interaction Core Facility housing five BIACORE instruments. The facility manager, David Myszka, holds the rank of Research Assistant Professor and is a world authority on biosensor studies. The largest equipment request is for a second analytical ultracentrifuge, a Beckman XL-I, to supplement the XL-A currently used at capacity. This expenditure, while significant, seems justified since the instrument would serve four of the five component projects. Overall, the facilities, their cost-effectiveness, and the quality of service appear to be excellent.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Utah
Salt Lake City
United States
Zip Code
Bayro, Marvin J; Ganser-Pornillos, Barbie K; Zadrozny, Kaneil K et al. (2016) Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles. J Am Chem Soc 138:12029-32
Votteler, Jörg; Sundquist, Wesley I (2013) Virus budding and the ESCRT pathway. Cell Host Microbe 14:232-41
Gan, Lu; Jensen, Grant J (2012) Electron tomography of cells. Q Rev Biophys 45:27-56
Guerrero-Ferreira, Ricardo C; Viollier, Patrick H; Ely, Bert et al. (2011) Alternative mechanism for bacteriophage adsorption to the motile bacterium Caulobacter crescentus. Proc Natl Acad Sci U S A 108:9963-8
Dobro, Megan J; Melanson, Linda A; Jensen, Grant J et al. (2010) Plunge freezing for electron cryomicroscopy. Methods Enzymol 481:63-82
Briegel, Ariane; Chen, Songye; Koster, Abraham J et al. (2010) Correlated light and electron cryo-microscopy. Methods Enzymol 481:317-41
Chen, Songye; McDowall, Alasdair; Dobro, Megan J et al. (2010) Electron cryotomography of bacterial cells. J Vis Exp :
Rich, Rebecca L; Miles, Adam R; Gale, Bruce K et al. (2009) Detergent screening of a G-protein-coupled receptor using serial and array biosensor technologies. Anal Biochem 386:98-104
Kieffer, Collin; Skalicky, Jack J; Morita, Eiji et al. (2008) Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell 15:62-73
Kim, Sunghwan; Pang, Hong-Bo; Kay, Michael S (2008) Peptide mimic of the HIV envelope gp120-gp41 interface. J Mol Biol 376:786-97

Showing the most recent 10 out of 32 publications