The Biophysics facility has instrumentation for analytical ultracentrifugation, microcalorimetery, CD, etc., as well as a Protein Interaction Core Facility housing five BIACORE instruments. The facility manager, David Myszka, holds the rank of Research Assistant Professor and is a world authority on biosensor studies. The largest equipment request is for a second analytical ultracentrifuge, a Beckman XL-I, to supplement the XL-A currently used at capacity. This expenditure, while significant, seems justified since the instrument would serve four of the five component projects. Overall, the facilities, their cost-effectiveness, and the quality of service appear to be excellent.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
1P01GM066521-01
Application #
6688176
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2002-08-15
Project End
2007-07-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Bayro, Marvin J; Ganser-Pornillos, Barbie K; Zadrozny, Kaneil K et al. (2016) Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles. J Am Chem Soc 138:12029-32
Votteler, Jörg; Sundquist, Wesley I (2013) Virus budding and the ESCRT pathway. Cell Host Microbe 14:232-41
Gan, Lu; Jensen, Grant J (2012) Electron tomography of cells. Q Rev Biophys 45:27-56
Guerrero-Ferreira, Ricardo C; Viollier, Patrick H; Ely, Bert et al. (2011) Alternative mechanism for bacteriophage adsorption to the motile bacterium Caulobacter crescentus. Proc Natl Acad Sci U S A 108:9963-8
Dobro, Megan J; Melanson, Linda A; Jensen, Grant J et al. (2010) Plunge freezing for electron cryomicroscopy. Methods Enzymol 481:63-82
Briegel, Ariane; Chen, Songye; Koster, Abraham J et al. (2010) Correlated light and electron cryo-microscopy. Methods Enzymol 481:317-41
Chen, Songye; McDowall, Alasdair; Dobro, Megan J et al. (2010) Electron cryotomography of bacterial cells. J Vis Exp :
Rich, Rebecca L; Miles, Adam R; Gale, Bruce K et al. (2009) Detergent screening of a G-protein-coupled receptor using serial and array biosensor technologies. Anal Biochem 386:98-104
Kieffer, Collin; Skalicky, Jack J; Morita, Eiji et al. (2008) Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell 15:62-73
Kim, Sunghwan; Pang, Hong-Bo; Kay, Michael S (2008) Peptide mimic of the HIV envelope gp120-gp41 interface. J Mol Biol 376:786-97

Showing the most recent 10 out of 32 publications