Core Structure The core will be overseen by Dr. Snyder and be managed by an Executive Committee comprised of Drs. Snyder, Wu, Weissman, Wysocka, and Koller. To avoid conflict of interest and to have a broader representation from the rest of the University, we will also have Dr. Irving Weissman (Director, Stanford Stem Cell Institute), Dr. Michael Longaker (co-Director, Stanford Stem Cell Institute), and Dr. Robert Robbins (Director, Stanford Cardiovascular Institute) as external panel members (see support letters). This core will meet biweekly physically (for the Stanford Pis) and by teleconference (for Weissman) and review scientific progress and discuss directions. The Executive Committee will also review pilot project proposals. It is expected that all decisions will be met by consensus, but in the unlikely event that this is not possible, Dr. Snyder is responsible for final decisions. The Executive Committee will also interface with other funded members of the consortium which will allow us to coordinate activities with other groups. If this format is not followed in this initiative, then an external advisory board comprised of prominent members in the iPSC and genomics communities will be formed and meet annually with our group. Scientific coordination will be mediated by Shin Lin, who is experienced with many of the techniques proposed and knows most of the Pis. He will be responsible for the day-to-day management of the entire operation. He will also be heavily engaged in Project 3. Communication between participants will be facilitated by Ms. Christina Pack, who will assist Dr. Snyder and also be responsible for interface with other members of the epigenetic consortium.

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Kim, Kun-Yong; Tanaka, Yoshiaki; Su, Juan et al. (2018) Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a. Nat Commun 9:2583
Patterson, Benjamin; Tanaka, Yoshiaki; Park, In-Hyun (2017) New Advances in Human X chromosome status from a Developmental and Stem Cell Biology. Tissue Eng Regen Med 14:643-652
Zhu, Wanjun; Zhang, Xiao-Yan; Marjani, Sadie L et al. (2017) Next-generation molecular diagnosis: single-cell sequencing from bench to bedside. Cell Mol Life Sci 74:869-880
Zhao, Ming-Tao; Shao, Ning-Yi; Hu, Shijun et al. (2017) Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells. Circ Res 121:1237-1250
Zhao, Ming-Tao; Chen, Haodong; Liu, Qing et al. (2017) Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proc Natl Acad Sci U S A 114:E11111-E11120
Xiang, Yangfei; Tanaka, Yoshiaki; Patterson, Benjamin et al. (2017) Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration. Cell Stem Cell 21:383-398.e7
Churko, Jared M; Lee, Jaecheol; Ameen, Mohamed et al. (2017) Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods. Nat Biomed Eng 1:826-837
Matsa, Elena; Burridge, Paul W; Yu, Kun-Hsing et al. (2016) Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell 19:311-25
Hu, Shijun; Zhao, Ming-Tao; Jahanbani, Fereshteh et al. (2016) Effects of cellular origin on differentiation of human induced pluripotent stem cell-derived endothelial cells. JCI Insight 1:
Hysolli, Eriona; Tanaka, Yoshiaki; Su, Juan et al. (2016) Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports 7:43-54

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