All animals live in constantly changing environments and are, therefore, subjected to fluctuations in critical environmental cues such as temperature. Given that all biochemical reactions are temperature sensitive to a certain extent, it is particularly critical for animals to compensate for these temperature changes in order to maintain steady internal conditions. In order to do so, animals must be able to detect small temperature changes and then trigger the appropriate homeostatic compensatory mechanisms. To date, research into the molecular and neuronal basis of temperature detection and thermotransduction, and the physiological mechanisms of temperature adaptation and compensation, have largely been pursued as independent lines of investigation. To obtain a full understanding of how animals respond appropriately to temperature changes, these intellectual issues must be brought together and studied as a whole. In this Program Project grant we bring together researchers experienced in issues of temperature detection and temperature compensation to ask how animals detect temperature changes and translate this information to effect compensatory changes in neuron function to maintain behavioral robustness. A particular strength of this proposal is the synergy among investigators exploring these issues in multiple systems;this diversity will elucidate common underlying principles that can be generalized ID other species. The overall questions being asked here are: 1) What are the molecular mechanisms by which animals detect temperature changes? 2) What are the neuronal mechanisms that encode information about temperature changes? 3) How do motor programs compensate for temperature fluctuations? 4) What defines the limits of the range in which these homeostatic mechanisms operate? 5) What are the common principles of temperature detection and compensation among species?

Public Health Relevance

Like cold-blooded animals, warm-blooded animals are also susceptible to the effects of alterations in their ability to correctly sense and compensate for temperature changes. 'Crashes'of nervous system function occur when compensation mechanisms fail. Understanding the limits of compensatory mechanisms will inform our understanding of critical medical issues such as febrile seizures, Uhthoff's phenomenon in multiple sclerosis, psychomotor stimulant drug-induced hypothermia and familial episodic pain syndrome among others.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM103770-02
Application #
8662278
Study Section
Special Emphasis Panel (ZRG1-CB-P (40))
Program Officer
Sesma, Michael A
Project Start
2013-05-15
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
2
Fiscal Year
2014
Total Cost
$1,273,608
Indirect Cost
$191,634
Name
Brandeis University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454
He, Li; Si, Guangwei; Huang, Jiuhong et al. (2018) Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel. Nature 555:103-106
Hawk, Josh D; Calvo, Ana C; Liu, Ping et al. (2018) Integration of Plasticity Mechanisms within a Single Sensory Neuron of C. elegans Actuates a Memory. Neuron 97:356-367.e4
Goodman, Miriam B; Sengupta, Piali (2018) The extraordinary AFD thermosensor of C. elegans. Pflugers Arch 470:839-849
Klein, Mason; Krivov, Sergei V; Ferrer, Anggie J et al. (2017) Exploratory search during directed navigation in C. elegans and Drosophila larva. Elife 6:
Knecht, Zachary A; Silbering, Ana F; Cruz, Joyner et al. (2017) Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila. Elife 6:
Shen, Yu; Wen, Quan; Liu, He et al. (2016) An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans. Elife 5:
Venkatachalam, Vivek; Ji, Ni; Wang, Xian et al. (2016) Pan-neuronal imaging in roaming Caenorhabditis elegans. Proc Natl Acad Sci U S A 113:E1082-8
van Giesen, Lena; Hernandez-Nunez, Luis; Delasoie-Baranek, Sophie et al. (2016) Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae. Nat Commun 7:10687
Takeishi, Asuka; Yu, Yanxun V; Hapiak, Vera M et al. (2016) Receptor-type Guanylyl Cyclases Confer Thermosensory Responses in C. elegans. Neuron 90:235-44
Narayan, Anusha; Venkatachalam, Vivek; Durak, Omer et al. (2016) Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 113:E1392-401

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