Abstract

This long-term research program seeks elucidation of genetic-biochemical parameters controlling differentiation and developmental processes in mammalian cells. A series of cell mutants, and hybrids is being prepared involving the standard Chinese hamster ovary culture; and cells from human and animal tissues taken at different stages of development and from various developmental disease situations. Studies will be conducted on the growth, morphological, and biochemical effects produced by cyclic AMP derivatives and selected hormones. The methodologies include somatic cell genetic analysis; study of biochemical pathways; immunogenetics; electrospin resonance and other membrane studies, scanning and transmission electron microscopy, two dimensional gel electrophoresis and molecular genetic analysis using recombinant DNA methods.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD002080-20
Application #
3096483
Study Section
Maternal and Child Health Research Committee (HDMC)
Project Start
1978-06-01
Project End
1988-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
20
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Storace, Douglas A; Higgins, Nathan C; Chikar, Jennifer A et al. (2012) Gene expression identifies distinct ascending glutamatergic pathways to frequency-organized auditory cortex in the rat brain. J Neurosci 32:15759-68
Storace, Douglas A; Higgins, Nathan C; Read, Heather L (2011) Thalamocortical pathway specialization for sound frequency resolution. J Comp Neurol 519:177-93
Higgins, Nathan C; Storace, Douglas A; Escabí, Monty A et al. (2010) Specialization of binaural responses in ventral auditory cortices. J Neurosci 30:14522-32
Storace, Douglas A; Higgins, Nathan C; Read, Heather L (2010) Thalamic label patterns suggest primary and ventral auditory fields are distinct core regions. J Comp Neurol 518:1630-46
Higgins, N C; Escabi, M A; Rosen, G D et al. (2008) Spectral processing deficits in belt auditory cortex following early postnatal lesions of somatosensory cortex. Neuroscience 153:535-49
Koka, Kanthaiah; Read, Heather L; Tollin, Daniel J (2008) The acoustical cues to sound location in the rat: measurements of directional transfer functions. J Acoust Soc Am 123:4297-309
Escabi, M A; Higgins, N C; Galaburda, A M et al. (2007) Early cortical damage in rat somatosensory cortex alters acoustic feature representation in primary auditory cortex. Neuroscience 150:970-83
Polley, Daniel B; Read, Heather L; Storace, Douglas A et al. (2007) Multiparametric auditory receptive field organization across five cortical fields in the albino rat. J Neurophysiol 97:3621-38
Law, M L; Chan, S D; Berger, R et al. (1990) The gene for the alpha 2 chain of the human fibrillar collagen type XI (COL11A2) assigned to the short arm of chromosome 6. Ann Hum Genet 54:23-9
Panini, S R; Lutz, R J; Wenger, L et al. (1990) Defective elongation of fatty acids in a recessive 25-hydroxycholesterol-resistant mutant cell line. J Biol Chem 265:14118-26

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