Project III The proposed study will examine two components of social communication in speakers withautism: conversational pragmatics, especially as these are impacted by the presence of narrow interests;and production and perception of prosody. These skills will be examined in a cross-sectional design at twodevelopmental levels: preadolescence and adolescence, and will contrast performance among speakers atall points on the Autism Spectrum Disorder with typical development. The studies grow out of our on-goinginterest in social communication and its manifestation in people with autism spectrum disorders (ASD) withhigh levels of intellectual and linguistic ability, but significant impairment in the capacity to achieve socialinteraction. Study 1 examines in depth the ability to produce appropriate speech acts in a structuredconversation, using a scripted, naturalistic interactive protocol that is designed to elicit specific speech actsand yields a quantitative measure of conversational skill. In addition to observing whether or not the targetspeech acts are produced, the protocol also uses a dynamic assessment format to provide a sequencedhierarchy of prompts, and rates the level of prompt needed to elicit acts that do not occur spontaneously. Anadditional aspect of the protocol is the assessment of impact of narrow interests on pragmatic performance.Performance on this protocol will be compared to a rating of pragmatic skills in an unstructured peerinteraction. This study has the potential to yield a standard quantitative, validated measure of pragmaticcompetence for use in clinical settings to evaluate pragmatic ability and measure change in treatment. Study2 extends our work on the role of prosody in social communication deficits in ASD. We propose to use anewly available measure of prosody, normed on typical children, to assess 3 levels of prosodic function --grammatical, pragmatic, and affective- in subjects with ASD. This study will also include fMRI work usingthe receptive prosody tasks. Patterns of prosodic production, and their change over the two developmentalperiods in the study, will also be examined, using both clinical and speech technology methods. These datawill be help to elucidate the relations between prosodic perception and production, identify prevalence andpatterns of prosodic deficits within ASD, and lead toward the development of intervention approaches toaddress these deficits.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD003008-40
Application #
7716929
Study Section
Special Emphasis Panel (ZHD1-DSR-H (FV))
Project Start
2008-09-01
Project End
2011-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
40
Fiscal Year
2008
Total Cost
$278,809
Indirect Cost
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Wang, Quan; Campbell, Daniel J; Macari, Suzanne L et al. (2018) Operationalizing atypical gaze in toddlers with autism spectrum disorders: a cohesion-based approach. Mol Autism 9:25
Charman, Tony; Young, Gregory S; Brian, Jessica et al. (2017) Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Res 10:169-178
Prince, Emily Barbara; Kim, Elizabeth S; Wall, Carla Anne et al. (2017) The relationship between autism symptoms and arousal level in toddlers with autism spectrum disorder, as measured by electrodermal activity. Autism 21:504-508
Messinger, Daniel S; Young, Gregory S; Webb, Sara Jane et al. (2016) Commentary: sex difference differences? A reply to Constantino. Mol Autism 7:31
Szatmari, Peter; Chawarska, Katarzyna; Dawson, Geraldine et al. (2016) Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions. J Am Acad Child Adolesc Psychiatry 55:179-87
Chawarska, Katarzyna; Macari, Suzanne; Powell, Kelly et al. (2016) Enhanced Social Attention in Female Infant Siblings at Risk for Autism. J Am Acad Child Adolesc Psychiatry 55:188-95.e1
Edgar, J Christopher; Fisk 4th, Charles L; Liu, Song et al. (2016) Translating Adult Electrophysiology Findings to Younger Patient Populations: Difficulty Measuring 40-Hz Auditory Steady-State Responses in Typically Developing Children and Children with Autism Spectrum Disorder. Dev Neurosci 38:1-14
Shic, Frederick (2016) Eye Tracking as a Behavioral Biomarker for Psychiatric Conditions: The Road Ahead. J Am Acad Child Adolesc Psychiatry 55:267-8
Chawarska, Katarzyna; Ye, Saier; Shic, Frederick et al. (2016) Multilevel Differences in Spontaneous Social Attention in Toddlers With Autism Spectrum Disorder. Child Dev 87:543-57
Coffman, M C; Anderson, L C; Naples, A J et al. (2015) Sex differences in social perception in children with ASD. J Autism Dev Disord 45:589-99

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