This application requests five years of continued support for an ongoing, multidisciplinary program of research on autism and related developmental disorders. The proposed work represents the evolution of the program project reflecting an increased focus on autism and related disorders. This application builds on important resources and research programs available at Yale. The broad theme that unifies this research program is the focus on understanding mechanisms of dysfunction in autism, and related conditions as they relate to development and outcome. The focus of the grant is on integrating advances in neuropsychology, developmental psychopathology, neuroscience and genetics into understanding the clinical manifestations, which in turn are studied in relation to specific neurodevelopmental processes and risk factors. Objectives include: 1) elucidating the earliest manifestations of autism from birth to 2 years through the prospective study of a large cohort of infants with a sibling who has autism;2) identifying predictors of outcome and clarify phenotypic variation in autism in a large group of school aged children, who were originally diagnosed with a pervasive developmental disorder at 2 years of age using a longitudinal design that will map trajectories across multiple domains of development;3) clarifying mechanisms in the development and expression of conversational pragmatics and prosody in high functioning individuals with ASD through studies using emerging technologies to examine conversational behaviors in greater depth and lay the foundation for developmental measures that can be used in clinical settings. In addition to these three projects three core resources are proposed and include: A) Administrative, B) Assessment C) Statistics &Research Design. This application brings together existing and new expertise, infrastructure and resources focused on diagnosis, early detection, causes, and treatment of autism. The work proposed is highly interdisciplinary drawing on both basic and clinical sciences and innovative research designs and state-of-the-art technologies. This work brings together, behavioral, biomedical, and clinical science investigators into a transdisciplinary program of research on autism.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-H (FV))
Program Officer
Kau, Alice S
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Yale University
Schools of Medicine
New Haven
United States
Zip Code
Wang, Quan; Campbell, Daniel J; Macari, Suzanne L et al. (2018) Operationalizing atypical gaze in toddlers with autism spectrum disorders: a cohesion-based approach. Mol Autism 9:25
Charman, Tony; Young, Gregory S; Brian, Jessica et al. (2017) Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Res 10:169-178
Prince, Emily Barbara; Kim, Elizabeth S; Wall, Carla Anne et al. (2017) The relationship between autism symptoms and arousal level in toddlers with autism spectrum disorder, as measured by electrodermal activity. Autism 21:504-508
Messinger, Daniel S; Young, Gregory S; Webb, Sara Jane et al. (2016) Commentary: sex difference differences? A reply to Constantino. Mol Autism 7:31
Szatmari, Peter; Chawarska, Katarzyna; Dawson, Geraldine et al. (2016) Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions. J Am Acad Child Adolesc Psychiatry 55:179-87
Chawarska, Katarzyna; Macari, Suzanne; Powell, Kelly et al. (2016) Enhanced Social Attention in Female Infant Siblings at Risk for Autism. J Am Acad Child Adolesc Psychiatry 55:188-95.e1
Edgar, J Christopher; Fisk 4th, Charles L; Liu, Song et al. (2016) Translating Adult Electrophysiology Findings to Younger Patient Populations: Difficulty Measuring 40-Hz Auditory Steady-State Responses in Typically Developing Children and Children with Autism Spectrum Disorder. Dev Neurosci 38:1-14
Shic, Frederick (2016) Eye Tracking as a Behavioral Biomarker for Psychiatric Conditions: The Road Ahead. J Am Acad Child Adolesc Psychiatry 55:267-8
Chawarska, Katarzyna; Ye, Saier; Shic, Frederick et al. (2016) Multilevel Differences in Spontaneous Social Attention in Toddlers With Autism Spectrum Disorder. Child Dev 87:543-57
Rowberry, Justin; Macari, Suzanne; Chen, Grace et al. (2015) Screening for autism spectrum disorders in 12-month-old high-risk siblings by parental report. J Autism Dev Disord 45:221-9

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