Abstract

The tau protein is involved in organizing microtubules which form and maintain the neuronal axon. The neuronal tau transcript produces multiple isoforms of the protein. The splicing mechanisms modulating the C-terminal variants of tau and the role they play in neurons during development and neurodegeneration will be elucidated.
The specific aims are to 1) isolate factors which inhibit the splicing of exon 10; 2) characterize trans factors involved in the alternative splicing of exon; and 3) study the expression and over-expression of the C- terminal variants during development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
2P01HD005515-32
Application #
6468928
Study Section
Project Start
1977-09-01
Project End
2005-11-30
Budget Start
Budget End
Support Year
32
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Eunice Kennedy Shriver Center Mtl Retardatn
Department
Type
DUNS #
City
Waltham
State
MA
Country
United States
Zip Code
02254

  Publications

Crandall, James E; Goodman, Timothy; McCarthy, Deirdre M et al. (2011) Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. J Neurochem 119:723-35
Crandall, James E; McCarthy, Deirdre M; Araki, Kiyomi Y et al. (2007) Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex. J Neurosci 27:3813-22
Wang, Junning; Tse, Sze-Wah; Andreadis, Athena (2007) Tau exon 6 is regulated by an intricate interplay of trans factors and cis elements, including multiple branch points. J Neurochem 100:437-45
Qu, Qiang; Crandall, James E; Luo, Tuanlian et al. (2006) Defects in tangential neuronal migration of pontine nuclei neurons in the Largemyd mouse are associated with stalled migration in the ventrolateral hindbrain. Eur J Neurosci 23:2877-86
McCaffery, Peter; Zhang, Jinghua; Crandall, James E (2006) Retinoic acid signaling and function in the adult hippocampus. J Neurobiol 66:780-91
Araki, Kiyomi Y; Fujimura, Satoshi; MacDonald, Marcy E et al. (2006) Characterization of mouse striatal precursor cell lines expressing functional dopamine receptors. Dev Neurosci 28:518-27
Leroy, Olivier; Wang, Junning; Maurage, Claude-Alain et al. (2006) Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1. Biochim Biophys Acta 1762:460-7
Leroy, Olivier; Dhaenens, Claire-Marie; Schraen-Maschke, Suzanna et al. (2006) ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I. J Neurosci Res 84:852-9
Qu, Qiang; Smith, Frances I (2005) Neuronal migration defects in cerebellum of the Largemyd mouse are associated with disruptions in Bergmann glia organization and delayed migration of granule neurons. Cerebellum 4:261-70
McCaffery, Peter; Deutsch, Curtis K (2005) Macrocephaly and the control of brain growth in autistic disorders. Prog Neurobiol 77:38-56

Showing the most recent 10 out of 180 publications