Abstract

The present multidisciplinary program represents a coordinated approach to the molecular characterization of fertilization ranging from sperm physiology and sperm-egg interaction phenomena to intraluminal conditions in the female reproductive tract and early development. Specific projects include: Energy Metabolism in Mammalian Spermatozoa (Storey), Cervical Mucus Production by Endocervical Cells in Culture (Nicosia), and the Role of Cortical Granules in Fertilization (Wolf). Supporting facilities include a tissue preparation area for light and electron microscopy, accommodations for patient-oriented research and a primate holding area.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD006274-20
Application #
3096577
Study Section
Population Research Committee (HDPR)
Project Start
1979-01-01
Project End
1991-12-31
Budget Start
1991-01-01
Budget End
1991-12-31
Support Year
20
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Cao, Wenlei; Ijiri, Takashi W; Huang, Andy P et al. (2011) Characterization of a novel tektin member, TEKT5, in mouse sperm. J Androl 32:55-69
Ijiri, Takashi W; Merdiushev, Tanya; Cao, Wenlei et al. (2011) Identification and validation of mouse sperm proteins correlated with epididymal maturation. Proteomics 11:4047-62
Cao, Wenlei; Aghajanian, Haig K; Haig-Ladewig, Lisa A et al. (2009) Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase. Biol Reprod 80:124-33
Zhang, Zhibing; Shen, Xuening; Jones, Brian H et al. (2008) Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2. Biol Reprod 79:75-83
Salvador, Lisa M; Silva, Celso P; Kostetskii, Igor et al. (2008) The promoter of the oocyte-specific gene, Gdf9, is active in population of cultured mouse embryonic stem cells with an oocyte-like phenotype. Methods 45:172-81
Selvaraj, Vimal; Asano, Atsushi; Buttke, Danielle E et al. (2006) Segregation of micron-scale membrane sub-domains in live murine sperm. J Cell Physiol 206:636-46
Yamaguchi, Ryo; Yamagata, Kazuo; Ikawa, Masahito et al. (2006) Aberrant distribution of ADAM3 in sperm from both angiotensin-converting enzyme (Ace)- and calmegin (Clgn)-deficient mice. Biol Reprod 75:760-6
Saner, Karla J; Suzuki, Takashi; Sasano, Hironobu et al. (2005) Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal. Mol Endocrinol 19:184-97
Hiroi, Hisahiko; Christenson, Lane K; Chang, Lisa et al. (2004) Temporal and spatial changes in transcription factor binding and histone modifications at the steroidogenic acute regulatory protein (stAR) locus associated with stAR transcription. Mol Endocrinol 18:791-806
Travis, Alexander J; Tutuncu, Levent; Jorgez, Carolina J et al. (2004) Requirements for glucose beyond sperm capacitation during in vitro fertilization in the mouse. Biol Reprod 71:139-45

Showing the most recent 10 out of 172 publications