The objective of this research proposal is to continue the collaborative activities of an established program project, involving five multidisciplinary research groups. These groups share clinical, biochemical, cellular and molecular biological knowledge to elucidate: (1) the molecular mechanisms of inborn errors of metabolism and environmental events associated with mental retardation (Projects I, II, and IV); (2) gene regulation (Projects I, II, III, V, and VI); (3) brain development and differentiation (Projects II, III, V, and VI); (4) metabolism of the brain and its component cell types (Projects I, II, and IV); and (5) signalling between different brain cells (Projects II, III, and V). These projects continue the emphasis on the neurobiological aspects of mental retardation and developmental disabilities. The investigators share: cell culture systems, molecular biology approaches, in vitro mutagenesis, gene transfer and transgenic animals. We expect this highly integrated and multidisciplinary program to provide major advancements in our understanding of the normal and abnormal development of neurons and glial cells. A major research effort is directed at elucidating the molecular mechanisms of oligodendrocyte differentiation in relation to its two known major functions: myelination and iron metabolism (Projects II, III, IV and V). All projects address the question of the influence of genes and the environment on development. The effort should lead to the development of concepts for specific therapeutic treatments for numerous CNS developmental disorders. In addition, this multidisciplinary program will provide a rich environment for the research training of graduate students and postdoctoral fellows.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD006576-20
Application #
3096591
Study Section
Mental Retardation Research Committee (HDMR)
Project Start
1983-09-30
Project End
1996-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
20
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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