Cellular Immune Responses to CMV in Cogneital and Perinatal Infections

Pass, Robert F.

Abstract

The purpose of this project is to further define through longitudinal study of human subjects the specific cellular immune responses of patients with congenital CMV infection and of young women during pregnancy and the postpartum period. In the former group we will examine the hypothesis that alterations of specific cellular immunity are associated with both the persistence of infection and occurrence of progressive deterioration. In the latter group (mothers) we will determine whether specific cell mediated immunity as measured by antigen stimulated lymphokine production and CMV specific responder cell frequency is a significant determinant of virus excretion during pregnancy and the postpartum interval or of transmission of CMV to offspring.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Research Program Projects (P01)
• Project #: 5P01HD010699-14
• Application #: 3878395
• Support Year: 14
• Fiscal Year: 1990

Institution

• Name: University of Alabama Birmingham
• DUNS #: 004514360
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35294

Publications

Pinninti, Swetha G; Rodgers, Mackenzie D; Novak, Zdenek et al. (2016) Clinical Predictors of Sensorineural Hearing Loss and Cognitive Outcome in Infants with Symptomatic Congenital Cytomegalovirus Infection. Pediatr Infect Dis J 35:924-6

Dreher, A Mackenzie; Arora, Nitin; Fowler, Karen B et al. (2014) Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr 164:855-9

Rosenthal, Lauren Stancik; Fowler, Karen B; Boppana, Suresh B et al. (2009) Cytomegalovirus shedding and delayed sensorineural hearing loss: results from longitudinal follow-up of children with congenital infection. Pediatr Infect Dis J 28:515-20

Ross, Shannon A; Novak, Zdenek; Fowler, Karen B et al. (2009) Cytomegalovirus blood viral load and hearing loss in young children with congenital infection. Pediatr Infect Dis J 28:588-92

Ross, Shannon A; Novak, Zdenek; Kumbla, Rekha A et al. (2007) GJB2 and GJB6 mutations in children with congenital cytomegalovirus infection. Pediatr Res 61:687-91

Ross, Shannon A; Fowler, Karen B; Ashrith, Guha et al. (2006) Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity. J Pediatr 148:332-6

Pass, Robert F; Fowler, Karen B; Boppana, Suresh B et al. (2006) Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome. J Clin Virol 35:216-20

Fowler, Karen B; Boppana, Suresh B (2006) Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol 35:226-31

Fowler, Karen B; Pass, Robert F (2006) Risk factors for congenital cytomegalovirus infection in the offspring of young women: exposure to young children and recent onset of sexual activity. Pediatrics 118:e286-92

Pryor, Shannon P; Demmler, Gail J; Madeo, Anne C et al. (2005) Investigation of the role of congenital cytomegalovirus infection in the etiology of enlarged vestibular aqueducts. Arch Otolaryngol Head Neck Surg 131:388-92