This program project renewal application is submitted by investigators who proposed to expand and continue their studies of the unique properties of human milk. The seven component subprojects address through in vivo protocols the biologic consequences of specific milk components or properties that the investigators have studied primarily in vitro during the initial funding period. In general, the subprojects seek to characterize the biologic interaction of milk components or properties at the interface of the milk with the GI lumen. Certain consequences of the luminal milk - GI tract interaction that pertain to the well-being of the infant also will be examined. When appropriate, human infants will be studied as subjects. Other neonatal mammals are utilized when human subjects are not appropriate for the protocol. In respective subprojects, we propose to consider: (1) whether lymphocytes and macrophages in human colostrum mediate protection to neonatal subjects via transfer of maternal cellular immunity and provision of accessory cell function, respectively; (2) the protective effect of milk in vivo against viral infections and (3) against Escherichia coli and Clostridium difficile diarrhea; (4) the pharmacokinetics of three new broad spectrum cephalosporin antibiotics administered to the lactating woman and the clinical significance for her nursing infant; (5) using stable isotope methods, the net absorption and balance of calcium, iron, and zinc in preterm infants fed human milk or formula and the effects of increasing postnatal age or milk fortification with these specific mineral nutrients; (6) the unique effects of postpartum age-specific milk on GI growth, motility, and intestinal and pancreatic functions; and (7) the protective effects of milk phospholipids on GI tract integrity as part of a continuum with amniotic fluid in the prevention of necrotizing enterocolitis.

Project Start
1979-07-01
Project End
1987-11-30
Budget Start
1986-07-01
Budget End
1987-11-30
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Reed, Benjamin D; Schibler, Kurt R; Deshmukh, Hitesh et al. (2018) The Impact of Maternal Antibiotics on Neonatal Disease. J Pediatr 197:97-103.e3
Young, Bridget E; Patinkin, Zachary W; Pyle, Laura et al. (2017) Markers of Oxidative Stress in Human Milk do not Differ by Maternal BMI But are Related to Infant Growth Trajectories. Matern Child Health J 21:1367-1376
Dingess, Kelly A; Valentine, Christina J; Ollberding, Nicholas J et al. (2017) Branched-chain fatty acid composition of human milk and the impact of maternal diet: the Global Exploration of Human Milk (GEHM) Study. Am J Clin Nutr 105:177-184
He, YingYing; Lawlor, Nathan T; Newburg, David S (2016) Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation. Adv Nutr 7:102-11
Vanchiere, John A; Carillo, Berenice; Morrow, Ardythe L et al. (2016) Fecal Polyomavirus Excretion in Infancy. J Pediatric Infect Dis Soc 5:210-3
Ward, Doyle V; Scholz, Matthias; Zolfo, Moreno et al. (2016) Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants. Cell Rep 14:2912-24
Newburg, David S; Ko, Jae Sung; Leone, Serena et al. (2016) Human Milk Oligosaccharides and Synthetic Galactosyloligosaccharides Contain 3'-, 4-, and 6'-Galactosyllactose and Attenuate Inflammation in Human T84, NCM-460, and H4 Cells and Intestinal Tissue Ex Vivo. J Nutr 146:358-67
He, YingYing; Liu, ShuBai; Kling, David E et al. (2016) The human milk oligosaccharide 2'-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation. Gut 65:33-46
Currier, Rebecca L; Payne, Daniel C; Staat, Mary A et al. (2015) Innate Susceptibility to Norovirus Infections Influenced by FUT2 Genotype in a United States Pediatric Population. Clin Infect Dis 60:1631-8
Newburg, David S; Morelli, Lorenzo (2015) Human milk and infant intestinal mucosal glycans guide succession of the neonatal intestinal microbiota. Pediatr Res 77:115-20

Showing the most recent 10 out of 292 publications