Abstract

Magnetic resonance imaging (MRI) is a powerful imaging modality due to its noninvasive character and the variety of anatomic, physiologic, and biochemical parameters that are measurable with this technique. The main goal of this Core is to use MRI to visualize the anatomic and physiologic abnormalities associated with the animal models of learning disabilities. This visualization will be based on a variety of MR parameters which emphasize different aspects of neuroanatomy and neurophysiology. Specifically, we will: (1) Visualize microgyria induced in rats to aid in the in vivo determination of location and severity of the lesion. (2) Visualize microglycia in ple mice; (3)Optimize and implement the proper parameters for the visualization of ectopias in mice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD020806-13
Application #
6108439
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
13
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Chen, Fuyi; Becker, Albert; LoTurco, Joseph (2016) Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery. Curr Protoc Pharmacol 72:14.37.1-12
Truong, Dongnhu T; Rendall, Amanda R; Rosen, Glenn D et al. (2015) Morphometric changes in subcortical structures of the central auditory pathway in mice with bilateral nodular heterotopia. Behav Brain Res 282:61-9
Che, Alicia; Girgenti, Matthew J; LoTurco, Joseph (2014) The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex. Biol Psychiatry 76:387-96
Siddiqi, Faez; Chen, Fuyi; Aron, Abraham W et al. (2014) Fate mapping by piggyBac transposase reveals that neocortical GLAST+ progenitors generate more astrocytes than Nestin+ progenitors in rat neocortex. Cereb Cortex 24:508-20
Fitch, R Holy; Alexander, Michelle L; Threlkeld, Steven W (2013) Early neural disruption and auditory processing outcomes in rodent models: implications for developmental language disability. Front Syst Neurosci 7:58
Truong, Dongnhu T; Bonet, Ashley; Rendall, Amanda R et al. (2013) A behavioral evaluation of sex differences in a mouse model of severe neuronal migration disorder. PLoS One 8:e73144
Tarkar, Aarti; Loges, Niki T; Slagle, Christopher E et al. (2013) DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet 45:995-1003
Chen, Fuyi; LoTurco, Joseph (2012) A method for stable transgenesis of radial glia lineage in rat neocortex by piggyBac mediated transposition. J Neurosci Methods 207:172-80
Maher, Brady J; LoTurco, Joseph J (2012) Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses. PLoS One 7:e34053
Threlkeld, Steven W; Hill, Courtney A; Szalkowski, Caitlin E et al. (2012) Effects of test experience and neocortical microgyria on spatial and non-spatial learning in rats. Behav Brain Res 235:130-5

Showing the most recent 10 out of 121 publications