The Program Director provides supervision and administration of this P01 through the Administrative Core (Core A). Primary Core A objectives are to (i) conduct overall day to day and long term management of the P01, (ii) interact closely with both the Internal and External Advisory Committees, (iii) provide support for the individual projects pertaining to experimental design, statistical analysis of the data and interpretation and presentation of experiment results, and (iv) facilitate sharing of our unique resource of non-human primate samples and data and exchange ideas generated by P01 participants with the wider scientific community. Core A will consist of the Director (Dr. Nathanielsz), an Associate Director (Dr. Nijiand), an Administrative Assistant (Karen Moore) and an Administrative Committee of Project and Core Pis. In its administrative capacity, this team will function to centralize program wide information, such as Institutional Animal Care And Use and Laboratory Safety records, and maintain records relating to Program progress. In its scientific capacity Core A will function to coordinate the overall direction of the program and the activities of the Internal and External Advisory Committees. The Internal Advisory Committee of distinguished and experienced School of Medicine and Texas Biomedical Research Institute faculty meets with the Core A team every 6 months to review progress. The External Advisory Committee will be made up of internationally recognized experts in maternal nutrition, fetal growth and development, maternal and fetal metabolism, and placental function. This Committee will meet once a year by Web Conference (GoToMeeting) with both Administrative and Internal Advisory Committees We regularly hold these meetings with other groups. For example we have held GoTo Meetings to discuss mutual interests with Dr. Romero's NICHD Internal Research Program Group in Detroit Both Internal and External Advisory Committees will present reports containing critical appraisal of progress of each project, core and the Program as a whole. These reports will be presented to the Program Director. Written response to recommendations by the advisory committees will be the responsibility of the appropriate Project or Core PI.

Public Health Relevance

Reduced fetal nutrient availability results in suboptimal fetal growth and development that increases the risk of lifelong ill health including the predisposition to diabetes and cardiovascular disease. This Program integrates decreased maternal nutrient availability with placental function, fetal nutrient availability and fetal brain and kidney development. We set out to study and identify key mechanisms in maternal x fetal nutrient environment interaction that will provide insight when designing treatment strategies.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1)
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University of Texas Health Science Center
San Antonio
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Kuo, Anderson H; Li, Cun; Huber, Hillary F et al. (2018) Ageing changes in biventricular cardiac function in male and female baboons (Papio spp.). J Physiol 596:5083-5098
Spradling-Reeves, Kimberly D; Glenn, Jeremy P; Lange, Kenneth J et al. (2018) The non-human primate kidney transcriptome in fetal development. J Med Primatol 47:157-171
Huber, Hillary F; Li, Cun; Nathanielsz, Peter W (2018) 2D:4D digit ratio is not a biomarker of developmental programming in baboons (Papio hamadryas species). J Med Primatol 47:78-80
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Kuo, A H; Li, J; Li, C et al. (2017) Prenatal steroid administration leads to adult pericardial and hepatic steatosis in male baboons. Int J Obes (Lond) 41:1299-1302
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Muralimanoharan, Sribalasubashini; Li, Cun; Nakayasu, Ernesto S et al. (2017) Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction. J Mol Cell Cardiol 108:181-193
Li, Cun; Jenkins, Susan; Mattern, Vicki et al. (2017) Effect of moderate, 30 percent global maternal nutrient reduction on fetal and postnatal baboon phenotype. J Med Primatol 46:293-303

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