Continued studies are proposed on a sample of 100 adults whose childhood reading history is well documented through archival information. Spouses and children of the probands will be recruited, as will some extended family members of selected, subjects. All subjects will undergo behavioral assessments, using procedures already shown to define the adult behavioral phenotype. From these assessments, the patterns of genetic transmission are examined with various analytic techniques, particularly segregation analysis. Electrophysiological studies, done in project IV on probands and their children, will be analyzed for transmission patterns of the electrophysiological phenotype.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Casanova, Ramon; Srikanth, Ryali; Baer, Aaron et al. (2007) Biological parametric mapping: A statistical toolbox for multimodality brain image analysis. Neuroimage 34:137-43
Chait, Maria; Eden, Guinevere; Poeppel, David et al. (2007) Delayed detection of tonal targets in background noise in dyslexia. Brain Lang 102:80-90
Goldston, David B; Walsh, Adam; Mayfield Arnold, Elizabeth et al. (2007) Reading problems, psychiatric disorders, and functional impairment from mid- to late adolescence. J Am Acad Child Adolesc Psychiatry 46:25-32
Daniel, Stephanie S; Walsh, Adam K; Goldston, David B et al. (2006) Suicidality, school dropout, and reading problems among adolescents. J Learn Disabil 39:507-14
Wood, Frank B; Hill, Deborah F; Meyer, Marianne S et al. (2005) Predictive assessment of reading. Ann Dyslexia 55:193-216
Hairston, W David; Burdette, Jonathan H; Flowers, D Lynn et al. (2005) Altered temporal profile of visual-auditory multisensory interactions in dyslexia. Exp Brain Res 166:474-80
Arnold, Elizabeth Mayfield; Goldston, David B; Walsh, Adam K et al. (2005) Severity of emotional and behavioral problems among poor and typical readers. J Abnorm Child Psychol 33:205-17
Flowers, D L; Jones, K; Noble, K et al. (2004) Attention to single letters activates left extrastriate cortex. Neuroimage 21:829-39
Eden, Guinevere F; Jones, Karen M; Cappell, Katherine et al. (2004) Neural changes following remediation in adult developmental dyslexia. Neuron 44:411-22
Grigorenko, Elena L; Wood, Frank B; Golovyan, Lina et al. (2003) Continuing the search for dyslexia genes on 6p. Am J Med Genet B Neuropsychiatr Genet 118B:89-98

Showing the most recent 10 out of 34 publications