The program represents the decision of multiple investigators to bring their individual techniques, systems and ideas to bear on a common theme. The central focus is the regulation of secretion and synthesis of the three pituitary gonadotropic hormones (FSH, LH and PRL), the analysis of their actions on the gonads and the feedback regulation by hormonal signals on the hypothalamic/pituitary unit. Particular emphasis is placed on the study of FSH because of the relative lack of information about his hormone compared to the other gonadotropins. The levels of investigation range from the whole animal to the molecular. The strong collaborations among the laboratories and projects have resulted in many important findings and an excellent publications record. The present application for renewal includes five research projects and an administrative core: PROJECT I. Differential Regulation of Gonadotropins by Glucocorticoids [Schwartz PI; Linzer CoPI] PROJECT II. Regulation of and Role of FSH in Photoperiodic Response [Turek PI; Levine Co-PI] PROJECT III. Protein Phosphorylation in Granulosa Cells [Hunzicker-Dunn PI] PROJECT IV. Inhibin and Activin: Synthesis, Activities, and Receptors [Mayo PI] PROJECT V. Regulation and Function of Ovarian Prolactin Receptors [Linzer PI; Hunzicker-Dunn Co-PI] CORE A. Administrative Core [Schwartz PD] The exchange of methodologies and ideas among investigators made possible by a Program Project Grant have fostered a broader perspective on the complexities of the hypothalamic-pituitary-gonadal axis than would have been possible with individual research grants. Indeed it is the interactions fostered by this Program Project Grant that have resulted in substantial progress being made in the past five years in understanding the control and action of FSH and the differences and similarities between FSH and the other gonadotropins.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD021921-09
Application #
2025144
Study Section
Population Research Committee (HDPR)
Project Start
1987-08-01
Project End
1998-11-30
Budget Start
1996-12-01
Budget End
1997-11-30
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Que, Emily L; Duncan, Francesca E; Bayer, Amanda R et al. (2017) Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy. Integr Biol (Camb) 9:135-144
Vanorny, Dallas A; Mayo, Kelly E (2017) The role of Notch signaling in the mammalian ovary. Reproduction 153:R187-R204
Xiao, Shuo; Duncan, Francesca E; Bai, Lu et al. (2015) Size-specific follicle selection improves mouse oocyte reproductive outcomes. Reproduction 150:183-92
Que, Emily L; Bleher, Reiner; Duncan, Francesca E et al. (2015) Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks. Nat Chem 7:130-9
Xiao, Shuo; Zhang, Jiyang; Romero, Megan M et al. (2015) In vitro follicle growth supports human oocyte meiotic maturation. Sci Rep 5:17323
Cordeiro, Marília H; Kim, So-Youn; Ebbert, Katherine et al. (2015) Geography of follicle formation in the embryonic mouse ovary impacts activation pattern during the first wave of folliculogenesis. Biol Reprod 93:88
Kong, Betty Y; Duncan, Francesca E; Que, Emily L et al. (2015) The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions. Dev Dyn 244:935-47
Kim, So-Youn; Ebbert, Katherine; Cordeiro, Marilia H et al. (2015) Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Endocrinology 156:1464-76
Makanji, Yogeshwar; Zhu, Jie; Mishra, Rama et al. (2014) Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev 35:747-94
Hong, Young Pyo; Gleber, Sophie-Charlotte; O'Halloran, Thomas V et al. (2014) Alignment of low-dose X-ray fluorescence tomography images using differential phase contrast. J Synchrotron Radiat 21:229-34

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