Previous studies implicate members of the Hedgehog (Hh) and Nodal signaling pathways in specification of the anterior central nervous system (CNS). The proposed studies are based on a specific hypothesis that postulates that Nodal and Hh signaling systems interact in a network. Experiments will test this hypothesis by analyzing loss and gain of function of components in both the Nodal and Hh pathways and by identifying the regulators of these pathways in a forward genetics mutagenesis screen.

Project Start
2002-07-18
Project End
2007-01-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
16
Fiscal Year
2002
Total Cost
$276,699
Indirect Cost
Name
University of Oregon
Department
Type
DUNS #
948117312
City
Eugene
State
OR
Country
United States
Zip Code
97403
Ferreira, Carlos R; Xia, Zhi-Jie; Clément, Aurélie et al. (2018) A Recurrent De Novo Heterozygous COG4 Substitution Leads to Saul-Wilson Syndrome, Disrupted Vesicular Trafficking, and Altered Proteoglycan Glycosylation. Am J Hum Genet 103:553-567
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