description): This program investigates the cellular and molecular mechanisms by which developing neural cells recognize, translate and respond to extracellular signals. Each of the participating Program laboratories examines the function and molecular mechanisms underlying distinct interactions of neural cells with their environment, including axonal recognition, synapse formation, plasticity, and oligodendrocyte precursor migration. Specifically, the functions and mechanisms of operation of cadherin, receptor-type, tyrosine kinases of the Eph-family and their ephrin-ligands, and membrane-bound proteoglycans will be investigated. Dr. Ranscht's project examines the role of T-cadherin in axonal pathway recognition and synapse formation in the hippocampus using mice with disrupted T- cadherin function. Dr. Yamaguchi's project addresses the function of proteoglycan syndecan-2 in dendritic spine maturation of hippocampal neurons Dr. Pasquale's project investigates the bi-directional signaling mechanisms of Ephbeta2 and its ephrin-B1 ligand, a receptor ligand pair that is expressed in hippocampal synapses. Dr. Stallcup's project determines the mechanism by which proteoglycan NG2 signals oligodendrocyte precursor cells to migrate.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Henken, Deborah B
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Sanford-Burnham Medical Research Institute
La Jolla
United States
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Yotsumoto, Fusanori; You, Weon-Kyoo; Cejudo-Martin, Pilar et al. (2015) NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization. Oncoimmunology 4:e1001204
Arranz, Amaia M; Perkins, Katherine L; Irie, Fumitoshi et al. (2014) Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space. J Neurosci 34:6164-76
Vargas, Lina M; Leal, Nancy; Estrada, Lisbell D et al. (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-? oligomers. PLoS One 9:e92309
You, Weon-Kyoo; Yotsumoto, Fusanori; Sakimura, Kenji et al. (2014) NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function. Angiogenesis 17:61-76
Cattaruzza, Sabrina; Ozerdem, Ugur; Denzel, Martin et al. (2013) Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells. Angiogenesis 16:309-27
Tigges, Ulrich; Komatsu, Masanobu; Stallcup, William B (2013) Adventitial pericyte progenitor/mesenchymal stem cells participate in the restenotic response to arterial injury. J Vasc Res 50:134-44
Falivelli, Giulia; Lisabeth, Erika Mathes; Rubio de la Torre, Elena et al. (2013) Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PLoS One 8:e81445
Noberini, Roberta; Koolpe, Mitchell; Lamberto, Ilaria et al. (2012) Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols. Pharmacol Res 66:363-73
Gibby, Krissa; You, Weon-Kyoo; Kadoya, Kuniko et al. (2012) Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan. Breast Cancer Res 14:R67
Noberini, Roberta; Rubio de la Torre, Elena; Pasquale, Elena B (2012) Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. Cell Adh Migr 6:102-12

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