Program project support is requested for a coordinated, multidisciplinary approach to investigate the role of milk-borne hormones and other active biological substances for the neonate. Support is requested for scientific projects and three cores (Morphological, Animal and Administrative). Three projects deal with the fate and effects of milk-borne peptide hormones in the suckling rats (Project #1. Role of Milk-Borne Somatostatin, PI: O. Koldovsky; Project #2. Metabolism of Milk-Borne Peptides, PI: T.P. Davis; and Project #5. Role of Nutrition and Milk-Borne Insulin-Like Growth Factors, PI: A.F. Philipps). These studied peptide hormones have important regulatory functions and may individually or collectively modulate the sensitivity of the developing gastrointestinal tract to necrotizing enterocolitis. Project #3. Role of Milk-Borne Carnitine, PI: C.A. Flores, deals with the role of milk-borne carnitine, an important factor in fat metabolism. Project #4. Role of Milk-Borne Biological Substances, PI: R. McCuskey, evaluates the role of these substances on the development of specific liver functions. These projects are supported by the three cores. The proposed studies are basic in nature, and the information derived will be applicable to a variety of normal and pathological conditions. Studies have demonstrated that some of these substances are absent in infant formulas, but present in human breast milk, emphasizing the significance of the proposed studies.
| Sørensen, Karen Kristine; Simon-Santamaria, Jaione; McCuskey, Robert S et al. (2015) Liver Sinusoidal Endothelial Cells. Compr Physiol 5:1751-74 |
| Kling, Pamela J; Willeitner, Andrea; Dvorak, Bohuslav et al. (2008) Enteral erythropoietin and iron stimulate erythropoiesis in suckling rats. J Pediatr Gastroenterol Nutr 46:202-7 |
| McCuskey, Robert S (2008) The hepatic microvascular system in health and its response to toxicants. Anat Rec (Hoboken) 291:661-71 |
| Kling, Pamela J; Taing, K Muy; Dvorak, Bohuslav et al. (2006) Insulin-like growth factor-I stimulates erythropoiesis when administered enterally. Growth Factors 24:218-23 |
| Dvorak, Bohuslav; Halpern, Melissa D; Holubec, Hana et al. (2004) Rat milk decreases necrotizing enterocolitis in a rat model. Adv Exp Med Biol 554:471-3 |
| Dvorak, Bohuslav; Fituch, Camellia C; Williams, Catherine S et al. (2004) Concentrations of epidermal growth factor and transforming growth factor-alpha in preterm milk. Adv Exp Med Biol 554:407-9 |
| Kling, Pamela J; Hutter, John J (2003) Hematologic abnormalities in severe neonatal necrotizing enterocolitis: 25 years later. J Perinatol 23:523-30 |
| Dvorak, Bohuslav; Fituch, Camellia C; Williams, Catherine S et al. (2003) Increased epidermal growth factor levels in human milk of mothers with extremely premature infants. Pediatr Res 54:15-9 |
| Halpern, Melissa D; Dominguez, Jessica A; Dvorakova, Katerina et al. (2003) Ileal cytokine dysregulation in experimental necrotizing enterocolitis is reduced by epidermal growth factor. J Pediatr Gastroenterol Nutr 36:126-33 |
| Halpern, Melissa D; Holubec, Hana; Dominguez, Jessica A et al. (2003) Hepatic inflammatory mediators contribute to intestinal damage in necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 284:G695-702 |
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