Abstract

The Core centralizes the care of our own breeding colony and makes a supply of suckling rats that are not affected by transportation from an outside, distant producer continuously available to investigators. The Core also provides for the individual investigators the means by which suckling rats can be fed rat milk or rat milk substitute (RMS) devoid of biologically-active substances (BAS) in a consistent, coordinated, and standardized manner. The Core additionally facilitates the supervision, training and maintenance of quality control for the many surgical procedures needed in this Program Project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD026013-06
Application #
6108548
Study Section
Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Sørensen, Karen Kristine; Simon-Santamaria, Jaione; McCuskey, Robert S et al. (2015) Liver Sinusoidal Endothelial Cells. Compr Physiol 5:1751-74
Kling, Pamela J; Willeitner, Andrea; Dvorak, Bohuslav et al. (2008) Enteral erythropoietin and iron stimulate erythropoiesis in suckling rats. J Pediatr Gastroenterol Nutr 46:202-7
McCuskey, Robert S (2008) The hepatic microvascular system in health and its response to toxicants. Anat Rec (Hoboken) 291:661-71
Kling, Pamela J; Taing, K Muy; Dvorak, Bohuslav et al. (2006) Insulin-like growth factor-I stimulates erythropoiesis when administered enterally. Growth Factors 24:218-23
Dvorak, Bohuslav; Halpern, Melissa D; Holubec, Hana et al. (2004) Rat milk decreases necrotizing enterocolitis in a rat model. Adv Exp Med Biol 554:471-3
Dvorak, Bohuslav; Fituch, Camellia C; Williams, Catherine S et al. (2004) Concentrations of epidermal growth factor and transforming growth factor-alpha in preterm milk. Adv Exp Med Biol 554:407-9
Kling, Pamela J; Hutter, John J (2003) Hematologic abnormalities in severe neonatal necrotizing enterocolitis: 25 years later. J Perinatol 23:523-30
Dvorak, Bohuslav; Fituch, Camellia C; Williams, Catherine S et al. (2003) Increased epidermal growth factor levels in human milk of mothers with extremely premature infants. Pediatr Res 54:15-9
Halpern, Melissa D; Dominguez, Jessica A; Dvorakova, Katerina et al. (2003) Ileal cytokine dysregulation in experimental necrotizing enterocolitis is reduced by epidermal growth factor. J Pediatr Gastroenterol Nutr 36:126-33
Halpern, Melissa D; Holubec, Hana; Dominguez, Jessica A et al. (2003) Hepatic inflammatory mediators contribute to intestinal damage in necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 284:G695-702

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