Abstract

Drs. Gilbert and Longo will each commit 10% of their time to the management of this Core. They will be assisted full-time by Larkin Buyak, a registered Veterinary Technician. The Core supports both the pregnant and non-pregnant sheep which the investigators justify as being able to provide adequate amounts of tissue as well as the conduct of the whole animal studies. The core is broken down into four main activity areas: Experimental animals; White Mountain Research Station, Loma Linda University (LLU) Animal Facilities and Laboratory Core Facilities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD031226-08
Application #
6564726
Study Section
Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
$195,628
Indirect Cost

  Institution

Name
Loma Linda University
Department
Type
DUNS #
City
Loma Linda
State
CA
Country
United States
Zip Code
92350

  Publications

Liu, Taiming; Zhang, Meijuan; Terry, Michael H et al. (2018) Nitrite potentiates the vasodilatory signaling of S-nitrosothiols. Nitric Oxide 75:60-69
Pearce, William J (2018) Fetal Cerebrovascular Maturation: Effects of Hypoxia. Semin Pediatr Neurol 28:17-28
Pearce, W J (2018) A path well travelled may lead to better stroke recovery. Acta Physiol (Oxf) 223:e13061
Vargas, Vladimir E; Myers, Dean A; Kaushal, Kanchan M et al. (2018) Expression of StAR and Key Genes Regulating Cortisol Biosynthesis in Near Term Ovine Fetal Adrenocortical Cells: Effects of Long-Term Hypoxia. Reprod Sci 25:230-238
Chuang, Tsai-Der; Sakurai, Reiko; Gong, Ming et al. (2018) Role of miR-29 in Mediating Offspring Lung Phenotype in a Rodent Model of Intrauterine Growth Restriction. Am J Physiol Regul Integr Comp Physiol :
Hu, Xiang-Qun; Huang, Xiaohui; Xiao, Daliao et al. (2016) Direct effect of chronic hypoxia in suppressing large conductance Ca(2+)-activated K(+) channel activity in ovine uterine arteries via increasing oxidative stress. J Physiol 594:343-56
Blum-Johnston, Carla; Thorpe, Richard B; Wee, Chelsea et al. (2016) Developmental acceleration of bradykinin-dependent relaxation by prenatal chronic hypoxia impedes normal development after birth. Am J Physiol Lung Cell Mol Physiol 310:L271-86
Goyal, Ravi; Billings, Tara L; Mansour, Trina et al. (2016) Vitamin D status and metabolism in an ovine pregnancy model: effect of long-term, high-altitude hypoxia. Am J Physiol Endocrinol Metab 310:E1062-71
Liu, Taiming; Schroeder, Hobe J; Wilson, Sean M et al. (2016) Local and systemic vasodilatory effects of low molecular weight S-nitrosothiols. Free Radic Biol Med 91:215-23
Myers, Dean A; Singleton, Krista; Kenkel, Christy et al. (2016) Gestational hypoxia modulates expression of corticotropin-releasing hormone and arginine vasopressin in the paraventricular nucleus in the ovine fetus. Physiol Rep 4:

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