Abstract

The purpose of the Sample Acquisition and informatics Core is four-fold; 1) recruitment and acquisition of samples from study subjects; 2) development and maintenance of data bases to ensure accurate data input, easy access to data and easy data transfer; 3) data entry; and 4) development of new statistical methods and analysis of data sets.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD032111-05
Application #
6108744
Study Section
Project Start
1999-03-01
Project End
2001-02-28
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Kokotas, Haris; Grigoriadou, Maria; Mikkelsen, Margareta et al. (2009) Investigating the impact of the Down syndrome related common MTHFR 677C>T polymorphism in the Danish population. Dis Markers 27:279-85
Lamb, N E; Sherman, S L; Hassold, T J (2005) Effect of meiotic recombination on the production of aneuploid gametes in humans. Cytogenet Genome Res 111:250-5
Lamb, Neil E; Yu, Kai; Shaffer, John et al. (2005) Association between maternal age and meiotic recombination for trisomy 21. Am J Hum Genet 76:91-9
Schueler, M G; Higgins, A W; Rudd, M K et al. (2001) Genomic and genetic definition of a functional human centromere. Science 294:109-15
Tsuchiya, K; Schueler, M G; Dev, V G (2001) Familial X centromere variant resulting in false-positive prenatal diagnosis of monosomy X by interphase FISH. Prenat Diagn 21:852-5
Brown, A S; Feingold, E; Broman, K W et al. (2000) Genome-wide variation in recombination in female meiosis: a risk factor for non-disjunction of chromosome 21. Hum Mol Genet 9:515-23
Hassold, T; Sherman, S; Hunt, P (2000) Counting cross-overs: characterizing meiotic recombination in mammals. Hum Mol Genet 9:2409-19
Feingold, E; Brown, A S; Sherman, S L (2000) Multipoint estimation of genetic maps for human trisomies with one parent or other partial data. Am J Hum Genet 66:958-68
Hassold, T; Sherman, S (2000) Down syndrome: genetic recombination and the origin of the extra chromosome 21. Clin Genet 57:95-100
Freeman, S B; Yang, Q; Allran, K et al. (2000) Women with a reduced ovarian complement may have an increased risk for a child with Down syndrome. Am J Hum Genet 66:1680-3

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