Core - Genetic Markers

Hassold, Terry J.

Abstract

The core will provide services that include design and synthesis of oligonucleotides for PCR analysis, development of multiplex protocols for genetic marker genotyping, and growth of plasmids, cosmids, or yeast strains (containing yeast artificial chromosomes) for use in the scientific projects. Each of these is an essential service required by multiple projects that will have to be duplicated, at considerable cost, in the absence of the core. This core will interact with all four projects and will provide significant cost savings by centralizing these services. c: john ja726

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Research Program Projects (P01)
• Project #: 5P01HD032111-05
• Application #: 6108745
• Project Start: 1999-03-01
• Project End: 2001-02-28
• Budget Start: 1998-10-01
• Budget End: 1999-09-30
• Support Year: 5
• Fiscal Year: 1999

Institution

• Name: Case Western Reserve University
• DUNS #: 077758407
• City: Cleveland
• State: OH
• Country: United States
• Zip Code: 44106

Publications

Kokotas, Haris; Grigoriadou, Maria; Mikkelsen, Margareta et al. (2009) Investigating the impact of the Down syndrome related common MTHFR 677C>T polymorphism in the Danish population. Dis Markers 27:279-85

Lamb, N E; Sherman, S L; Hassold, T J (2005) Effect of meiotic recombination on the production of aneuploid gametes in humans. Cytogenet Genome Res 111:250-5

Lamb, Neil E; Yu, Kai; Shaffer, John et al. (2005) Association between maternal age and meiotic recombination for trisomy 21. Am J Hum Genet 76:91-9

Tsuchiya, K; Schueler, M G; Dev, V G (2001) Familial X centromere variant resulting in false-positive prenatal diagnosis of monosomy X by interphase FISH. Prenat Diagn 21:852-5

Schueler, M G; Higgins, A W; Rudd, M K et al. (2001) Genomic and genetic definition of a functional human centromere. Science 294:109-15

Brown, A S; Feingold, E; Broman, K W et al. (2000) Genome-wide variation in recombination in female meiosis: a risk factor for non-disjunction of chromosome 21. Hum Mol Genet 9:515-23

Hassold, T; Sherman, S; Hunt, P (2000) Counting cross-overs: characterizing meiotic recombination in mammals. Hum Mol Genet 9:2409-19

Feingold, E; Brown, A S; Sherman, S L (2000) Multipoint estimation of genetic maps for human trisomies with one parent or other partial data. Am J Hum Genet 66:958-68

Hassold, T; Sherman, S (2000) Down syndrome: genetic recombination and the origin of the extra chromosome 21. Clin Genet 57:95-100

Freeman, S B; Yang, Q; Allran, K et al. (2000) Women with a reduced ovarian complement may have an increased risk for a child with Down syndrome. Am J Hum Genet 66:1680-3