; Throughout life, the nervous system acquires and maintains many different motor skills. These skills rely on the spinal circuits that determine the interactions between the spinal cord, which excites the muscles, and the peripheral apparatus that produces movements and provides sensory feedback. It is now clear that the brain continually adjusts these circuits to support new skills, to maintain older skills, and to reduce the functional impact of aging, trauma, and disease. The goal of this project is to advance understanding of how the brain exerts the long-term control over these circuits that keeps the spinal cord and the periphery working together effectively, and to apply that understanding to develop new therapeutic methods. Animals and humans can gradually change the spinal stretch reflex (SSR) or its electrical analog, the Hreflex, in response to an operant conditioning protocol. These reflex changes are simple motor skills (i.e.,

Public Health Relevance

This work should help to explain how brain and spinal cord work together to maintain effective spinal musculoskeletal interactions. They should also guide development of new methods for restoring effective interactions and thereby improving function after trauma or disease. Reflex conditioning protocols could target the specific deficits of each individual, and might thereby complement existing rehabilitation methods.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD032571-17
Application #
8511108
Study Section
Special Emphasis Panel (ZHD1-RRG-K)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
17
Fiscal Year
2013
Total Cost
$230,221
Indirect Cost
$23,683
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Eftekhar, Amir; Norton, James J S; McDonough, Christine M et al. (2018) Retraining Reflexes: Clinical Translation of Spinal Reflex Operant Conditioning. Neurotherapeutics :
Norton, James J S; Wolpaw, Jonathan R (2018) Acquisition, Maintenance, and Therapeutic Use of a Simple Motor Skill. Curr Opin Behav Sci 20:138-144
Gregor, Robert J; Maas, Huub; Bulgakova, Margarita A et al. (2018) Time course of functional recovery during the first 3 mo after surgical transection and repair of nerves to the feline soleus and lateral gastrocnemius muscles. J Neurophysiol 119:1166-1185
Chen, Yi; Chen, Lu; Wang, Yu et al. (2017) Why New Spinal Cord Plasticity Does Not Disrupt Old Motor Behaviors. J Neurosci 37:8198-8206
Pantall, Annette; Hodson-Tole, Emma F; Gregor, Robert J et al. (2016) Increased intensity and reduced frequency of EMG signals from feline self-reinnervated ankle extensors during walking do not normalize excessive lengthening. J Neurophysiol 115:2406-20
Chen, Xiang Yang; Wang, Yu; Chen, Yi et al. (2016) Ablation of the inferior olive prevents H-reflex down-conditioning in rats. J Neurophysiol 115:1630-6
Gordon, Tessa; English, Arthur W (2016) Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise. Eur J Neurosci 43:336-50
Zhu, Xiya; Ward, Patricia J; English, Arthur W (2016) Selective Requirement for Maintenance of Synaptic Contacts onto Motoneurons by Target-Derived trkB Receptors. Neural Plast 2016:2371893
Farrell, Brad J; Bulgakova, Margarita A; Sirota, Mikhail G et al. (2015) Accurate stepping on a narrow path: mechanics, EMG, and motor cortex activity in the cat. J Neurophysiol 114:2682-702
Krakowiak, Joey; Liu, Caiyue; Papudesu, Chandana et al. (2015) Neuronal BDNF signaling is necessary for the effects of treadmill exercise on synaptic stripping of axotomized motoneurons. Neural Plast 2015:392591

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