Joint use of Core facilities is a crucial activity in the operation of a Program Project. This Cell Biology and Physiology Core brings in investigators of 4 projects to facilitate access to specialized technologies and newer methods.
The aims of this Core are to provide: 1) technical assistance and training in electrophysiologic and molecular biologic techniques and approaches to investigators and supporting staff; 2) central consultative service for interpretation of data; 3) centralized facility for confocal microscopy which includes the study of ionic fluxes (e.g. Ca++, H+) and cytoskeletal and membrane proteins in live and fixed tissues for measurements of protein synthesis, amino-acid incorporation etc. and 4) a facility for fabrication and utilization of patch clamp, ion-selective microelectrodes for intracellular and extracellular ionic measurements. We believe that this Core will foster interactions between investigators and results from one project may affect the subsequent design and protocols in others within the program as we detailed in the overall introduction of this program above.
| Azad, Priti; Zhao, Huiwen W; Cabrales, Pedro J et al. (2016) Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med 213:2729-2744 |
| Yao, Hang; Azad, Priti; Zhao, Huiwen W et al. (2016) The Na+/HCO3- co-transporter is protective during ischemia in astrocytes. Neuroscience 339:329-337 |
| Jha, Aashish R; Zhou, Dan; Brown, Christopher D et al. (2016) Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol 33:501-17 |
| Pamenter, Matthew E; Haddad, Gabriel G (2015) High-throughput cell death assays. Methods Mol Biol 1254:153-63 |
| Gu, Xiang Q; Pamenter, Matthew E; Siemen, Detlef et al. (2014) Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma. Glia 62:504-13 |
| Gersten, Merril; Zhou, Dan; Azad, Priti et al. (2014) Wnt pathway activation increases hypoxia tolerance during development. PLoS One 9:e103292 |
| Udpa, Nitin; Ronen, Roy; Zhou, Dan et al. (2014) Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol 15:R36 |
| Salameh, Ahlam Ibrahim; Ruffin, Vernon A; Boron, Walter F (2014) Effects of metabolic acidosis on intracellular pH responses in multiple cell types. Am J Physiol Regul Integr Comp Physiol 307:R1413-27 |
| Parker, Mark D; Boron, Walter F (2013) The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev 93:803-959 |
| Romero, Michael F; Chen, An-Ping; Parker, Mark D et al. (2013) The SLC4 family of bicarbonate (HCOýýýýýý) transporters. Mol Aspects Med 34:159-82 |
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