The purpose of Core A is to further the aims ofthe Program Project grant by centralizing administrative activities. Centralization has several benefits. These include: 1) improved efficiency, 2) improved cost effectiveness and 3) enhanced professional interaction. Core A is an administrative core and will cover 1) administration, 2) bookkeeping, 3) secretarial support, 4) isotope administration, 5) statistical support, 6) consultation for programming and 7) consultation for echocardiography. Core A includes office support for all projects and the other three cores, blood gas and isotope service for sheep projects, statistical support and overall consultation by Professor Barker. One role ofthe administrative core will be to provide a suitable research environment for members of the Program Project. Core A will provide such an environment by means ofthe following: 1) Developmental Origins of Health and Disease Study Group. This group of investigators and students meet 2X/month under the coordination of Dr. Susan Bagby to discuss research. There are some 40 scientists who belong to this lively group. Susan was the primary planner for the 7th World Congress on the Developmental Origins of Health and Disease in Portland, September 18-21, 2011. 2) Try on For Size (TOPS) weekly research conference. This conference has an emphasis on cardiovascular biology and is attended by researchers from Cardiology, Pediatric Cardiology, Cardiac Surgery, Physiology &Pharmacology and Obstetrics &Gynecology. This conference has been running continuously for about 35 years. 3) Endothelial Chalk Talk monthly conference. This conference convenes all the people at OHSU who are interested in endothelial biology. This conference is run by Dr. Owen McCarty, PhD, an engineer from the Department of Biomedical Engineering. 4) Visiting Scientist Program: Every year well known scientists are invited to OHSU to exchange ideas and some are asked to evaluate the PPG and participate in an annual science day which highlights developmental heart disease research.

Public Health Relevance

Core A provides for the administrative needs ofthe Program Project and also enriches the academic environment by providing opportunities of scientific interaction with visiting guests and local scientists.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
2P01HD034430-16A1
Application #
8521759
Study Section
Special Emphasis Panel (ZHD1-DSR-Z (41))
Project Start
Project End
Budget Start
2013-06-07
Budget End
2014-03-31
Support Year
16
Fiscal Year
2013
Total Cost
$188,318
Indirect Cost
$66,034
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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Midgett, Madeline; Thornburg, Kent; Rugonyi, Sandra (2017) Blood flow patterns underlie developmental heart defects. Am J Physiol Heart Circ Physiol 312:H632-H642
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Jonker, S S; Louey, S (2016) Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment. J Endocrinol 228:R1-18
Burton, Graham J; Fowden, Abigail L; Thornburg, Kent L (2016) Placental Origins of Chronic Disease. Physiol Rev 96:1509-65
Barry, James S; Rozance, Paul J; Brown, Laura D et al. (2016) Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood) 241:839-47
Thornburg, Kent L; Kolahi, Kevin; Pierce, Melinda et al. (2016) Biological features of placental programming. Placenta 48 Suppl 1:S47-S53
Chadderdon, Scott M; Belcik, J Todd; Bader, Lindsay et al. (2016) Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance. Diabetes 65:2249-57

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