Abstract

The major focus of Project II is the analysis of oxidized lipids and oxidized LDL in peritoneal fluid (PF) of women with endometriosis and those who do not show evidence of this disorder. The underlying hypothesis is that these oxidized products and other products generated by interaction of oxidized lipids with proteins serve as mediators for the recruitment of leukocytes into the peritoneal cavity and for the production of inflammatory cytokines and growth factors. These factors are thought to stimulate proliferation of endometrial cells. The generation of oxidized products is suggested to adversely affect sperm/egg interactions and to account for infertility in women with endometriosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD035276-04
Application #
6564752
Study Section
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
2002
Total Cost
$165,355
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Santanam, Nalini; Zoneraich, Nathaniel; Parthasarathy, Sampath (2017) Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF. Reprod Sci 24:619-626
Santanam, Nalini; Kavtaradze, Nino; Murphy, Ana et al. (2012) Antioxidant supplementation reduces endometriosis-related pelvic pain in humans. Transl Res :
Budrys, Nicole M; Nair, Hareesh B; Liu, Ya-Guang et al. (2012) Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis. Fertil Steril 97:1129-35.e1
Griffith, Jason S; Binkley, Peter A; Kirma, Namir B et al. (2010) Imatinib decreases endometrial stromal cell transmesothial migration and proliferation in the extracellular matrix of modeled peritoneum. Fertil Steril 94:2531-5
Park, John K; Song, MingQing; Dominguez, Celia E et al. (2006) Glycodelin mediates the increase in vascular endothelial growth factor in response to oxidative stress in the endometrium. Am J Obstet Gynecol 195:1772-7
Cao, Xuan; Yang, Dongzi; Song, Mingqing et al. (2004) The presence of endometrial cells in the peritoneal cavity enhances monocyte recruitment and induces inflammatory cytokines in mice: implications for endometriosis. Fertil Steril 82 Suppl 3:999-1007
Wanichkul, Thitikorn; Han, Shouwei; Huang, Ruo-Pan et al. (2003) Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells. Fertil Steril 79 Suppl 1:763-9
Han, Shouwei; Inoue, Hiroyasu; Flowers, Lisa C et al. (2003) Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells. Clin Cancer Res 9:4627-35
Song, Mingqing; Karabina, Sonia A; Kavtaradze, Nino et al. (2003) Presence of endometrial epithelial cells in the peritoneal cavity and the mesothelial inflammatory response. Fertil Steril 79 Suppl 1:789-94
Han, Shouwei; Sidell, Neil (2003) RU486-induced growth inhibition of human endometrial cells involves the nuclear factor-kappa B signaling pathway. J Clin Endocrinol Metab 88:713-9

Showing the most recent 10 out of 19 publications