Abstract

This project intends to study the issue of regression in children who develop autism by examining early videotapes of 100 preschoolers with autism, compared to early videotapes of normal developing children. A comparison group without autism but with low IQ is also involved. Younger siblings of the children with autism form a fourth subject group. The researchers plan to classify the children with autism into one of three """"""""onset"""""""" groups based on videotapes taken during the children's infancy; the three groups involved are: no regression, language regression only, and full autistic regression, which will include signs of regression in social and communicative areas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD035458-05
Application #
6572338
Study Section
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
2002-03-01
Budget End
2003-02-28
Support Year
5
Fiscal Year
2002
Total Cost
$108,050
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Fujikawa-Brooks, Sharon; Isenberg, A Lisette; Osann, Kathryn et al. (2010) The effect of rate stress on the auditory brainstem response in autism: a preliminary report. Int J Audiol 49:129-40
Ramanathan, Subhadra; Woodroffe, Abigail; Flodman, Pamela L et al. (2004) A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC Med Genet 5:10
Palmer, Abraham A; Breen, Laura L; Flodman, Pamela et al. (2003) Identification of quantitative trait loci for prepulse inhibition in rats. Psychopharmacology (Berl) 165:270-9
Smith, M; Woodroffe, A; Smith, R et al. (2002) Molecular genetic delineation of a deletion of chromosome 13q12-->q13 in a patient with autism and auditory processing deficits. Cytogenet Genome Res 98:233-9
Smith, M; Escamilla, J R; Filipek, P et al. (2001) Molecular genetic delineation of 2q37.3 deletion in autism and osteodystrophy: report of a case and of new markers for deletion screening by PCR. Cytogenet Cell Genet 94:15-22
Owley, T; McMahon, W; Cook, E H et al. (2001) Multisite, double-blind, placebo-controlled trial of porcine secretin in autism. J Am Acad Child Adolesc Psychiatry 40:1293-9