Abstract

Project II focuses on cognitive variables that may be part of the extended phenotype present in first-degree relatives of individuals with autism. Specifically, this project will focus on the executive function abilities of family members of autistic probands. Initial cognitive studies of parents and siblings focused on general impairments (e.g., mental retardation, learning disabilities), providing mixed evidence for a cognitive endophenotype. More recent investigations focusing on specific cognitive impairments that may aggregate in the families of autistic probands have been more promising, however. Project II concentrates on the integrity of one specific set of neuropsychological processes, executive functions, in family members of autistic probands. To examine whether executive deficits are stratified as a function of proband intellectual level, performance of parents/siblings of non-retarded autistic individuals will be compared with parents/siblings of children with learning disabilities (matched on IQ to autistic probands), while parents/siblings of mentally retarded autistic children will be compared to parents/siblings of probands with Down Syndrome (again matched on IQ to autistic subjects).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD035476-02
Application #
6272429
Study Section
Project Start
1998-06-01
Project End
1999-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Prigge, Molly D; Bigler, Erin D; Fletcher, P Thomas et al. (2013) Longitudinal Heschl's gyrus growth during childhood and adolescence in typical development and autism. Autism Res 6:78-90
Lange, Nicholas; Dubray, Molly B; Lee, Jee Eun et al. (2010) Atypical diffusion tensor hemispheric asymmetry in autism. Autism Res 3:350-8
Chung, Moo K; Adluru, Nagesh; Lee, Jee Eun et al. (2010) Cosine series representation of 3D curves and its application to white matter fiber bundles in diffusion tensor imaging. Stat Interface 3:69-80
Chung, Moo K; Adluru, Nagesh; Lee, Jee Eun et al. (2009) Efficient parametric encoding scheme for white matter fiber bundles. Conf Proc IEEE Eng Med Biol Soc 2009:6644-7
Han, Deok; Singh, Vikas; Lee, Jee Eun et al. (2009) An experimental evaluation of diffusion tensor image segmentation using graph-cuts. Conf Proc IEEE Eng Med Biol Soc 2009:5653-6
Adluru, Nagesh; Hinrichs, Chris; Chung, Moo K et al. (2009) Classification in DTI using shapes of white matter tracts. Conf Proc IEEE Eng Med Biol Soc 2009:2719-22
Glessner, Joseph T; Wang, Kai; Cai, Guiqing et al. (2009) Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 459:569-73
Mazefsky, Carla A; Folstein, Susan E; Lainhart, Janet E (2008) Overrepresentation of mood and anxiety disorders in adults with autism and their first-degree relatives: what does it mean? Autism Res 1:193-7
South, Mikle; Ozonoff, Sally; Suchy, Yana et al. (2008) Intact emotion facilitation for nonsocial stimuli in autism: is amygdala impairment in autism specific for social information? J Int Neuropsychol Soc 14:42-54
Dominick, Kelli C; Davis, Naomi Ornstein; Lainhart, Janet et al. (2007) Atypical behaviors in children with autism and children with a history of language impairment. Res Dev Disabil 28:145-62

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